{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T21:29:43Z","timestamp":1790026183149,"version":"4.0.1"},"reference-count":41,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,5,17]],"date-time":"2013-05-17T00:00:00Z","timestamp":1368748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:sec>\n                    <jats:title>Study Objective<\/jats:title>\n                    <jats:p>\n                      To identify predictors of hospital admissions associated with adverse drug events (\n                      <jats:styled-content style=\"fixed-case\">ADE<\/jats:styled-content>\n                      s) and to determine the preventability of\n                      <jats:styled-content style=\"fixed-case\">ADE<\/jats:styled-content>\n                      s in patients admitted to two hospitals.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Prospective observational study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Medical admission units at two British National Health Service hospitals in the United Kingdom.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients<\/jats:title>\n                    <jats:p>3904 adults age 16\u00a0years or older who were admitted to the two hospitals between June 2006 and November 2007.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>\n                      Clinical pharmacists identified hospital admissions associated with drug\u2010related problems by using medical record review, supplemented by patient interview for those identified as having an\n                      <jats:styled-content style=\"fixed-case\">ADE<\/jats:styled-content>\n                      . The contribution of\n                      <jats:styled-content style=\"fixed-case\">ADE<\/jats:styled-content>\n                      s to hospital admission and the causality, severity, and preventability of the events were independently assessed by a multidisciplinary clinical team. Multivariate logistic regression was used to identify predictors of hospital admissions associated with\n                      <jats:styled-content style=\"fixed-case\">ADE<\/jats:styled-content>\n                      s, and a maximum\u2010likelihood multinomial model was used to examine predictors of the preventability of\n                      <jats:styled-content style=\"fixed-case\">ADE<\/jats:styled-content>\n                      s. Of the 3904 patients included in the analysis, 439 (11.2%) were judged by the review panel to have experienced\n                      <jats:styled-content style=\"fixed-case\">ADE<\/jats:styled-content>\n                      s. Of these, 209 patients (47.6%) experienced preventable\n                      <jats:styled-content style=\"fixed-case\">ADE<\/jats:styled-content>\n                      s. Four independent variables were found to have significant relationships with\n                      <jats:styled-content style=\"fixed-case\">ADE<\/jats:styled-content>\n                      admissions and preventability of\n                      <jats:styled-content style=\"fixed-case\">ADE<\/jats:styled-content>\n                      s: patient age, length of time since starting new drug, total number of prescription drugs, and hospital site. Drug classes most commonly associated with preventable\n                      <jats:styled-content style=\"fixed-case\">ADE<\/jats:styled-content>\n                      s were antiplatelet drugs, anticoagulants, diuretics (loop and thiazide diuretics), angiotensin\u2010converting enzyme inhibitors, and antiepileptic drugs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Adverse drug events are an important cause of hospital admission. Better systems for health care practitioners to identify patients at high risk of preventable hospital admissions associated with\n                      <jats:styled-content style=\"fixed-case\">ADE<\/jats:styled-content>\n                      s (e.g., age &gt;\u00a065\u00a0years old, receiving more than five drugs, and starting new high\u2010risk drugs) should be implemented in order to minimize the risks to patients and the burden on the health care system.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/phar.1287","type":"journal-article","created":{"date-parts":[[2013,5,17]],"date-time":"2013-05-17T10:04:08Z","timestamp":1368785048000},"page":"827-837","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":113,"title":["Risk Factors for Hospital Admissions Associated with Adverse Drug Events"],"prefix":"10.1002","volume":"33","author":[{"given":"Chuenjid","family":"Kongkaew","sequence":"first","affiliation":[{"name":"Centre for Pharmacoepidemiology and Drug Safety Research School of Pharmacy and Pharmaceutical Sciences Manchester Academic Health Sciences Centre (MAHSC) University of Manchester Manchester UK"},{"name":"Faculty of Pharmaceutical Sciences Naresuan University Naresuan Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Hann","sequence":"additional","affiliation":[{"name":"Primary Care Research Group School of Community Based Medicine Manchester Academic Health Sciences Centre (MAHSC) University of Manchester Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaydeep","family":"Mandal","sequence":"additional","affiliation":[{"name":"South Manchester University Hospitals NHS Foundation Trust Manchester Academic Health Sciences Centre (MAHSC) Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven D.","family":"Williams","sequence":"additional","affiliation":[{"name":"Centre for Pharmacoepidemiology and Drug Safety Research School of Pharmacy and Pharmaceutical Sciences Manchester Academic Health Sciences Centre (MAHSC) University of Manchester Manchester UK"},{"name":"South Manchester University Hospitals NHS Foundation Trust Manchester Academic Health Sciences Centre (MAHSC) Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Metcalfe","sequence":"additional","affiliation":[{"name":"Wrightington, Wigan &amp; Leigh Health Services NHS Trust Greater Manchester Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter R.","family":"Noyce","sequence":"additional","affiliation":[{"name":"Centre for Pharmacoepidemiology and Drug Safety Research School of Pharmacy and Pharmaceutical Sciences Manchester Academic Health Sciences Centre (MAHSC) University of Manchester Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren M.","family":"Ashcroft","sequence":"additional","affiliation":[{"name":"Centre for Pharmacoepidemiology and Drug Safety Research School of Pharmacy and Pharmaceutical Sciences Manchester Academic Health Sciences Centre (MAHSC) University of Manchester Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,5,17]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"An organisation with a memory: report of an expert group on learning from adverse event in the NHS","author":"Department of Health","year":"2000"},{"key":"e_1_2_7_3_1","volume-title":"To err is human: building a safer health system","author":"Institute of Medicine","year":"2000"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1H658"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.329.7456.15"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1L037"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6963-11-134"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1P627"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.1030683"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/qhc.12.4.280"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.568"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2002.tb01647.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1445-5994.2001.00044.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/jamia.2001.0080254"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2004.05.008"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.1074"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03530010043033"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.159.21.2553"},{"key":"e_1_2_7_19_1","volume-title":"Safety of medicines: a guide to detecting and reporting adverse drug reactions","author":"World Health Organization","year":"2002"},{"key":"e_1_2_7_20_1","first-page":"1","volume-title":"Compliance in health care","author":"Haynes RB","year":"1979"},{"issue":"2","key":"e_1_2_7_21_1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1093\/ajhp\/55.2.165","article-title":"Suggested definitions and relationships among medication misadventures, medication errors, adverse drug events, and adverse drug reactions","volume":"55","author":"Anon","year":"1998","journal-title":"Am J Health Syst Pharm"},{"key":"e_1_2_7_22_1","unstructured":"Anon.MedDRA data retrieval and presentation: points to consider. Available fromhttp:\/\/www.meddramsso.com\/PTC\/drp_ptc_r33.html 2012."},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.1990.tb00199.x"},{"key":"e_1_2_7_24_1","volume-title":"Seven steps to patient safety for primary care","author":"The National Patient Safety Agency","year":"2005"},{"issue":"3","key":"e_1_2_7_25_1","first-page":"533","article-title":"Opportunities and responsibilities in pharmaceutical care","volume":"47","author":"Hepler CD","year":"1990","journal-title":"Am J Hosp Pharm"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.1586"},{"key":"e_1_2_7_27_1","volume-title":"British national formulary","author":"British Medical Association and the Royal Pharmaceutical Society of Great Britain","year":"2012"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.15.1858"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-11-200712040-00006"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2004.52367.x"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1988.tb04395.x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1992.tb04001.x"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.157.1.60"},{"key":"e_1_2_7_34_1","volume-title":"Medicines and older people: implementing medicines\u2010related aspects of the NSF for older people","author":"Department of Health","year":"2001"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002280050582"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61817-5"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-007-9134-y"},{"key":"e_1_2_7_38_1","volume-title":"New medicine service guidance","author":"Pharmaceutical Services Negotiating Committee","year":"2011"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0269-4727.2003.00461.x"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1177\/070674370304800406"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.15288\/jsad.2011.72.774"},{"issue":"7","key":"e_1_2_7_42_1","first-page":"372","article-title":"Ambulatory care visits for treating adverse drug effects in the United States, 1995\u20132001","volume":"31","author":"Zhan C","year":"2005","journal-title":"Jt Comm J Qual Patient Saf"}],"container-title":["Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fphar.1287","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fphar.1287","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/phar.1287","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T17:32:57Z","timestamp":1761067977000},"score":1,"resource":{"primary":{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/10.1002\/phar.1287"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,17]]},"references-count":41,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["10.1002\/phar.1287"],"URL":"https:\/\/doi.org\/10.1002\/phar.1287","archive":["Portico"],"relation":{},"ISSN":["0277-0008","1875-9114"],"issn-type":[{"value":"0277-0008","type":"print"},{"value":"1875-9114","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,17]]},"assertion":[{"value":"2013-05-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}