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Moreover, novel interventions for antimicrobial stewardship programs are integral to combating antimicrobial resistance worldwide. One unique method that may decrease the use of second\u2010line antibiotics (e.g., fluoroquinolones, vancomycin) while facilitating access to a preferred \u03b2\u2010lactam regimen in numerous health care settings is a penicillin skin test. Provided that up to 10% of patients have a reported penicillin allergy, of whom ~10% have true IgE\u2013mediated hypersensitivity, significant potential exists to utilize a penicillin skin test to safely identify those who may receive penicillin or a \u03b2\u2010lactam antibiotic. In this article, we provide information on the background, associated costs, currently available literature, pharmacists' role, antimicrobial stewardship implications, potential barriers, and misconceptions, as well as future directions associated with the penicillin skin test.<\/jats:p>","DOI":"10.1002\/phar.1288","type":"journal-article","created":{"date-parts":[[2013,5,27]],"date-time":"2013-05-27T00:31:55Z","timestamp":1369614715000},"page":"856-867","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["Penicillin Skin Testing: Potential Implications for Antimicrobial Stewardship"],"prefix":"10.1002","volume":"33","author":[{"given":"Nathan R.","family":"Unger","sequence":"first","affiliation":[{"name":"Department of Pharmacy Practice Nova Southeastern University College of Pharmacy Palm Beach Gardens Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy P.","family":"Gauthier","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice Nova Southeastern University College of Pharmacy Fort Lauderdale Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda W.","family":"Cheung","sequence":"additional","affiliation":[{"name":"Pharmacy Service, James A. 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