{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T04:53:05Z","timestamp":1773809585715,"version":"3.50.1"},"reference-count":11,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,7,8]],"date-time":"2013-07-08T00:00:00Z","timestamp":1373241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:p>\n                    Amiodarone is an effective treatment for atrial and ventricular arrhythmias, but its use is limited by a toxic adverse\u2010effect profile. Although dronedarone has been touted as an antiarrhythmic agent devoid of both solid organ toxicity and proarrhythmic properties, its potential for prolonging ventricular repolarization may augment triggered ectopy. We describe a 66\u2010year\u2010old man who began dronedarone 400\u00a0mg twice\/day for new\u2010onset paroxysmal atrial fibrillation; he had no left ventricular dysfunction or clinical heart failure. Three months after starting the drug, he complained of malaise, fatigue, and rare palpitations. Twenty four\u2013hour Holter monitoring revealed increased premature ventricular complexes, and the rate\u2010corrected\n                    <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>\n                    (\n                    <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>\n                    c) interval was prolonged (range 525\u2013760\u00a0msec). Dronedarone was discontinued and the patient's symptoms gradually resolved over the next 3\u00a0weeks. Holter monitoring revealed a marked reduction in ventricular ectopy burden, and the\n                    <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>\n                    c interval decreased to his baseline values. Even in the absence of documented symptomatic torsade de pointes, this case suggests that caution should be exercised when prescribing dronedarone and that serial\n                    <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>\n                    c interval monitoring may be appropriate. In addition, clinicians should have a low threshold to perform Holter monitoring if symptoms develop during dronedarone therapy.\n                  <\/jats:p>","DOI":"10.1002\/phar.1330","type":"journal-article","created":{"date-parts":[[2013,7,8]],"date-time":"2013-07-08T12:14:31Z","timestamp":1373285671000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Ventricular Ectopy and QTc\u2010Interval Prolongation Associated with Dronedarone Therapy"],"prefix":"10.1002","volume":"33","author":[{"given":"Jaime E.","family":"Gonzalez","sequence":"first","affiliation":[{"name":"University of Colorado School of Medicine Division of Cardiology Aurora Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William H.","family":"Sauer","sequence":"additional","affiliation":[{"name":"University of Colorado School of Medicine Division of Cardiology Aurora Colorado"},{"name":"CPC clinical Research Aurora Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mori J.","family":"Krantz","sequence":"additional","affiliation":[{"name":"University of Colorado School of Medicine Division of Cardiology Aurora Colorado"},{"name":"CPC clinical Research Aurora Colorado"},{"name":"Denver Health and Hospitals Denver Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,7,8]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.298.11.1312"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.1746"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0b013e3182377a11"},{"key":"e_1_2_5_5_1","unstructured":"Food and Drug Administration.FDA Product Label Dronedarone September 2012. Available fromhttp:\/\/www.accessdata.fda.gov\/scripts\/cder\/drugsatfda\/index\/cfm?fuseaction=Seach.Label_ApprovalHistory#labelinfo. Accessed March 22 2013."},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(01)00259-0"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2004.03534.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0803778"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc4701.099579"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1109867"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1875-9114.2012.01118.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"}],"container-title":["Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fphar.1330","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fphar.1330","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/phar.1330","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T17:19:51Z","timestamp":1761067191000},"score":1,"resource":{"primary":{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/10.1002\/phar.1330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,8]]},"references-count":11,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["10.1002\/phar.1330"],"URL":"https:\/\/doi.org\/10.1002\/phar.1330","archive":["Portico"],"relation":{},"ISSN":["0277-0008","1875-9114"],"issn-type":[{"value":"0277-0008","type":"print"},{"value":"1875-9114","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,8]]},"assertion":[{"value":"2013-07-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}