{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:59:23Z","timestamp":1788872363204,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,8,12]],"date-time":"2013-08-12T00:00:00Z","timestamp":1376265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Pharmaceutical Sciences Research Center"},{"name":"Iranian Registry of Clinical Trials","award":["IRCT201102273449N4"],"award-info":[{"award-number":["IRCT201102273449N4"]}]}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:sec>\n                    <jats:title>Study Objective<\/jats:title>\n                    <jats:p>To evaluate the effects of topical atorvastatin on the healing process of pressure ulcers in critically ill patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Randomized, double\u2010blind, placebo\u2010controlled clinical trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Medical\u2010surgical intensive care unit of a university\u2010affiliated teaching hospital in Tehran, Iran.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients<\/jats:title>\n                    <jats:p>\n                      One hundred four patients with stage I or\n                      <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\n                      pressure ulcers, graded according to the 2\u2010digit Stirling Pressure Sore Severity Scale.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Intervention<\/jats:title>\n                    <jats:p>Patients were randomized to receive topical atorvastatin 1% ointment (51 patients [atorvastatin group]) or placebo ointment (53 patients [control group]) applied once\/day to pressure ulcers for 14\u00a0days in addition to standard care for pressure ulcers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>\n                      The efficacy of each treatment was assessed on days 7 and 14. Efficacy was determined based on the degree of healing of the existing pressure ulcer by using the 2\u2010digit Stirling scale. The baseline stage of the pressure ulcers did not differ significantly between the control and atorvastatin groups. However, the mean\u00a0\u00b1\u00a0\n                      <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\n                      stage of pressure ulcers significantly decreased in the atorvastatin group compared with the control group on day 7 (0.97\u00a0\u00b1\u00a00.76 vs 1.74\u00a0\u00b1\u00a00.75, p&lt;0.01) and day 14 (0.42\u00a0\u00b1\u00a00.67 vs 1.71\u00a0\u00b1\u00a00.78, p&lt;0.01) of treatment. In addition, the mean\u00a0\u00b1\u00a0\n                      <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\n                      surface areas of ulcers in the atorvastatin group were significantly declined compared with the control group after 7\u00a0days (5.55\u00a0\u00b1\u00a04.55 vs 9.41\u00a0\u00b1\u00a05.03\u00a0cm\n                      <jats:sup>2<\/jats:sup>\n                      , p&lt;0.01) and 14\u00a0days (3.72\u00a0\u00b1\u00a04.45 vs 10.41\u00a0\u00b1\u00a06.41\u00a0cm\n                      <jats:sup>2<\/jats:sup>\n                      , p&lt;0.01) of treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Topical application of atorvastatin ointment 1% for 14\u00a0days in addition to standard care significantly accelerated the healing of stage I or\n                      <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\n                      pressure ulcers in critically ill patients.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/phar.1339","type":"journal-article","created":{"date-parts":[[2013,8,12]],"date-time":"2013-08-12T09:25:55Z","timestamp":1376299555000},"page":"19-27","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Efficacy of Topical Atorvastatin for the Treatment of Pressure Ulcers: A Randomized Clinical Trial"],"prefix":"10.1002","volume":"34","author":[{"given":"Shadi","family":"Farsaei","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy Department of Clinical Pharmacy Pharmaceutical Sciences Research Center Tehran University of Medical Sciences Tehran Iran"},{"name":"Department of Clinical Pharmacy and Pharmacy Practice School of Pharmacy Isfahan University of Medical Sciences Isfahan 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