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The basal insulin products currently on the market, although improved, do not optimally mimic endogenous insulin secretion. It is therefore important to investigate how the action of a basal insulin can be improved to match the physiologic profile more precisely and consequently to examine the desired properties of an ideal new\u2010generation basal insulin. Some of these characteristics would include stable pharmacokinetic (PK) and pharmacodynamic (PD) profiles, true 24\u2010hour duration of action in all patients, low within\u2010person variability in absorption and glucose\u2010lowering action, more flexible dose timing, and low occurrence of hypoglycemia. A new\u2010generation basal insulin, insulin degludec, currently approved in Japan, Mexico, and Europe, was designed to provide a more stable pharmacotherapeutic option with a lower risk of hypoglycemia than the currently available basal insulins while retaining an efficacious profile. The characteristics of an ideal basal insulin are reviewed, and the pharmacology and clinical attributes of insulin degludec are discussed.<\/jats:p>","DOI":"10.1002\/phar.1361","type":"journal-article","created":{"date-parts":[[2013,10,17]],"date-time":"2013-10-17T05:33:42Z","timestamp":1381988022000},"page":"291-302","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["A New Option for Glycemic Control: Insulin Degludec, a New\u2010Generation Basal Insulin with an Ultralong Duration of Action"],"prefix":"10.1002","volume":"34","author":[{"given":"Scott R.","family":"Drab","sequence":"first","affiliation":[{"name":"University of Pittsburgh School of Pharmacy Pittsburgh Pennsylvania"},{"name":"University Diabetes Care Associates Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athena","family":"Philis\u2010Tsimikas","sequence":"additional","affiliation":[{"name":"Scripps Whittier 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