{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:35:32Z","timestamp":1761093332276,"version":"build-2065373602"},"reference-count":67,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,11,11]],"date-time":"2013-11-11T00:00:00Z","timestamp":1384128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:p>Acute decompensated heart failure (<jats:styled-content style=\"fixed-case\">ADHF<\/jats:styled-content>) is associated with substantial morbidity and mortality, and represents a considerable financial burden to society. Historically, few prospective, randomized, double\u2010blinded trials have investigated the optimal management of <jats:styled-content style=\"fixed-case\">ADHF<\/jats:styled-content>, and most guideline recommendations are based primarily on expert opinion. However, in the last decade, a considerable amount of research has added to the understanding of the management of <jats:styled-content style=\"fixed-case\">ADHF<\/jats:styled-content> in both patients with fluid overload and low cardiac output. In addition, as mechanical circulatory support devices and heart transplantation continue to evolve, significant advances have also been made with regard to the proper selection of patients for advanced surgical options. Finally, several novel pharmacologic agents have shown promise in early trials and may represent the next steps in <jats:styled-content style=\"fixed-case\">ADHF<\/jats:styled-content> management. Although advances have been made over the past decade, many questions remain.<\/jats:p>","DOI":"10.1002\/phar.1369","type":"journal-article","created":{"date-parts":[[2013,11,11]],"date-time":"2013-11-11T07:36:58Z","timestamp":1384155418000},"page":"373-388","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Acute Decompensated Heart Failure: Evolving Literature and Implications for Future Practice"],"prefix":"10.1002","volume":"34","author":[{"given":"Jonathan D.","family":"Cicci","sequence":"first","affiliation":[{"name":"Department of Pharmacy University of North Carolina Hospitals and Clinics Chapel Hill North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brent N.","family":"Reed","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice and Science University of Maryland School of Pharmacy Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth B.","family":"McNeely","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Rex Hospital Raleigh North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akinyemi","family":"Oni\u2010Orisan","sequence":"additional","affiliation":[{"name":"Eshelman School of Pharmacy University of North Carolina Chapel Hill North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Herbert","family":"Patterson","sequence":"additional","affiliation":[{"name":"Eshelman School of Pharmacy University of North Carolina Chapel Hill North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo E.","family":"Rodgers","sequence":"additional","affiliation":[{"name":"Eshelman School of Pharmacy University of North Carolina Chapel Hill North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,11,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.12.1531"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.12.1541"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2010.04.004"},{"key":"e_1_2_7_5_1","first-page":"e240","article-title":"2013 ACCF\/AHA Guideline for the Management of Heart Failure A Report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines","volume":"128","author":"Yancy CW","year":"2013","journal-title":"Circulation"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197612092952406"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2009.11.005"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2010.01.355"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1005419"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.06.034"},{"key":"e_1_2_7_11_1","first-page":"787","article-title":"Combination of furosemide and metolazone in the treatment of severe congestive heart failure","volume":"22","author":"Grosskopf I","year":"1986","journal-title":"Isr J Med Sci"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.71.2.146"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000082314"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1989.246"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-114-10-886"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192064"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.553370"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs104"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1994.298"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.07.051"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2010.07.246"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03495-4"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-142-7-200504050-00010"},{"key":"e_1_2_7_24_1","unstructured":"GiamouzisG.The dopamine in acute decompensated heart failure II trial. Abstract 285. Presented at the European Society of Cardiology Heart Failure Congress 2013 Lisbon Portugal May 25\u201028 2013."},{"volume-title":"Renal optimization strategies evaluation in acute heart failure and Reliable Evaluation of Dyspnea in the Heart Failure Network (ROSE) Study (ROSE\/RED ROSE)","year":"2000","author":"Duke University; National Heart, Lung, and Blood Institute","key":"e_1_2_7_25_1"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2003.09.051"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000297161.41559.93"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11897-009-0026-4"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.03.051"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.02.083"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs0880159"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200007273430403"},{"issue":"3","key":"e_1_2_7_33_1","first-page":"H1049","article-title":"Coronary vasodilator effects of BNP: mechanisms of action in coronary conductance and resistance arteries","volume":"276","author":"Zellner C","year":"1999","journal-title":"Am J Physiol"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.12.1465"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000159340.93220.E4"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.15.1900"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2008.07.031"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1100171"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.590091"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2006.09.014"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.11.025"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.297.12.1319"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.297.12.1332"},{"key":"e_1_2_7_44_1","unstructured":"Food and Drug Administration.Samsca (tolvaptan): Drug Safety Communication \u2013 FDA limits duration and usage due to possible liver injury leading to organ transplant or death. [Internet]. Available fromhttp:\/\/www.fda.gov\/Safety\/MedWatch\/SafetyInformation\/SafetyAlertsforHumanMedicalProducts\/ucm350185.htm. Accessed May 16 2013."},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.3111\/13696998.2011.643329"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.2459\/JCM.0b013e328355a740"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1080\/17482940701210179"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.07.073"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2009.12.009"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1210357"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02134-4"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1136\/heart.89.6.621"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5273(01)00520-4"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.59.3.297"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(99)70110-9"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(94)00543-Y"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejheart.2007.05.011"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.12.040"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp323"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.03.048"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012175"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0909938"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.10.062"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2011.12.001"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2011.08.003"},{"key":"e_1_2_7_66_1","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/j.healun.2011.03.019","article-title":"Changing outcomes in patients bridged to heart transplantation with continuous\u2010 versus pulsatile\u2010flow ventricular assist devices: an analysis of the registry of the International Society for Heart and Lung Transplantation","volume":"30","author":"Nativi JN","year":"2011","journal-title":"J Heart Lung Transplant"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.691972"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61855-8"}],"container-title":["Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fphar.1369","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fphar.1369","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/phar.1369","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T11:08:57Z","timestamp":1761044937000},"score":1,"resource":{"primary":{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/10.1002\/phar.1369"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,11]]},"references-count":67,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["10.1002\/phar.1369"],"URL":"https:\/\/doi.org\/10.1002\/phar.1369","archive":["Portico"],"relation":{},"ISSN":["0277-0008","1875-9114"],"issn-type":[{"type":"print","value":"0277-0008"},{"type":"electronic","value":"1875-9114"}],"subject":[],"published":{"date-parts":[[2013,11,11]]},"assertion":[{"value":"2013-11-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}