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Traditional treatment with manufactured hormone therapy can alleviate these symptoms, but many women and their health care providers are concerned about the risks, such as venous thromboembolism and certain types of cancer, demonstrated with manufactured hormone therapy. Compounded bioidentical hormone therapy has been proposed and is often used as a solution for these concerns. Despite this use, no data are currently available to support the claims that compounded bioidentical hormone therapy is a safer or more efficacious option compared with manufactured hormone therapy. A common misperception is that all manufactured products consist of synthetic hormones and all compounded medications consist of natural hormones; however, in fact, significant overlap exists. Several key stakeholder organizations have issued statements expressing concern about the lack of evidence regarding the efficacy and safety of compounded bioidentical hormone therapy, in addition to concerns regarding prescribing patterns. The Women's Health Practice and Research Network of the American College of Clinical Pharmacy recommends against the consistent use of compounded bioidentical hormones as a safer option compared with manufactured therapy and supports the statements of other key organizations, acknowledging the need for more robust clinical studies to evaluate the potential advantages and disadvantages of compounded bioidentical products compared with manufactured products.<\/jats:p>","DOI":"10.1002\/phar.1394","type":"journal-article","created":{"date-parts":[[2014,1,4]],"date-time":"2014-01-04T01:11:10Z","timestamp":1388797870000},"page":"410-423","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Use of Compounded Bioidentical Hormone Therapy in Menopausal Women: An Opinion Statement of the Women's Health Practice and Research Network of the American College of Clinical Pharmacy"],"prefix":"10.1002","volume":"34","author":[{"given":"Sarah E.","family":"McBane","sequence":"first","affiliation":[{"name":"Skaggs School of Pharmacy and Pharmaceutical Sciences University of California, San Diego La Jolla California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura M.","family":"Borgelt","sequence":"additional","affiliation":[{"name":"Departments of Clinical Pharmacy and Family Medicine Skaggs School of Pharmacy and Pharmaceutical Sciences University of Colorado Anschutz Medical Campus Aurora Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kylie N.","family":"Barnes","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice and Administration University of Missouri Kansas City Kansas City Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah M.","family":"Westberg","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Care and Health Systems University of Minnesota College of Pharmacy Minneapolis Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole M.","family":"Lodise","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice Albany College of Pharmacy and Health Sciences Albany New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha","family":"Stassinos","sequence":"additional","affiliation":[{"name":"Women's Health and Ambulatory Care VA Northern California Health Care System Oakland California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,1,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/13697130701744696"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/gme.0b013e31824b970a"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.13.1739"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0029-7844(94)00383-O"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.3.321"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwn090"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djq527"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61526-9"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.1500"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djq285"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60534-0"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djj375"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.20.2651"},{"key":"e_1_2_7_15_1","first-page":"153","article-title":"Bioidentical hormones: an evidence\u2010based review for primary care providers","volume":"111","author":"Conaway E","year":"2011","journal-title":"J Am Osteopath Assoc"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/13697137.2013.771520"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.06.002"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-2509"},{"key":"e_1_2_7_19_1","unstructured":"American Medical Association House of Delegates Resolution 706.FDA Oversight of Bio\u2010identical Hormone (BH) Preparations."},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/13697130701361657"},{"key":"e_1_2_7_21_1","unstructured":"CobinRHPS BledsoeMB BorgWP et al.American Association of Clinical Endocrinologists (AACE) Reproductive Medicine Committee Position Statement on Bioidentical Hormones updated 7\/15\/2007. 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