{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T14:51:12Z","timestamp":1777560672140,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,5,7]],"date-time":"2014-05-07T00:00:00Z","timestamp":1399420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:sec><jats:title>Study Objective<\/jats:title><jats:p>To determine whether preadmission statin use in patients with spontaneous subarachnoid hemorrhage (<jats:styled-content style=\"fixed-case\">SAH<\/jats:styled-content>) is associated with improved functional outcomes and a lower incidence of delayed cerebral ischemic events compared with statin\u2010naive patients with <jats:styled-content style=\"fixed-case\">SAH<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Neurosciences intensive care unit of a tertiary care hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>A total of 295 consecutive patients with <jats:styled-content style=\"fixed-case\">SAH<\/jats:styled-content> admitted between March 2006 and May 2013 who had complete medication histories; of these patients, 41 reported taking a statin prior to admission, and 254 were statin naive.<\/jats:p><\/jats:sec><jats:sec><jats:title>Intervention<\/jats:title><jats:p>All patients received clinical management for <jats:styled-content style=\"fixed-case\">SAH<\/jats:styled-content> according to hospital protocol for standard care that included acute statin therapy with enteral pravastatin 40\u00a0mg\/day on hospital day 1 for up to 21\u00a0days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements and Main Results<\/jats:title><jats:p>Functional outcomes were assessed by using the modified Rankin Scale (<jats:styled-content style=\"fixed-case\">mRS<\/jats:styled-content>) at 14\u00a0days, 28\u00a0days, and 3\u00a0months. Delayed cerebral ischemia was assessed by using clinical evaluation and computed tomography. Patients taking statins prior to admission were more likely to have a history of diabetes mellitus, hypertension, coronary artery disease, and stroke. No significant difference in favorable neurologic outcome (<jats:styled-content style=\"fixed-case\">mRS<\/jats:styled-content> score 0\u20133) at 3\u00a0months was observed between the preadmission statin group compared with the statin\u2010naive group (56.3% vs 72.4%, p=0.095). In multivariate logistic regression analysis, only age, severity of rupture, and coronary artery disease were less likely to predict a favorable neurologic outcome. No significant difference in the development of delayed cerebral ischemic events was observed between groups (p=0.48).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Statin use prior to admission did not improve functional outcomes or prevent delayed cerebral ischemic events in patients with <jats:styled-content style=\"fixed-case\">SAH<\/jats:styled-content>. Age, severity of rupture, and coronary artery disease were less likely to predict a favorable neurologic outcome at 3\u00a0months after discharge.<\/jats:p><\/jats:sec>","DOI":"10.1002\/phar.1436","type":"journal-article","created":{"date-parts":[[2014,5,7]],"date-time":"2014-05-07T09:32:55Z","timestamp":1399455175000},"page":"811-817","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Preadmission Statin Use Does Not Improve Functional Outcomes or Prevent Delayed Ischemic Events in Patients with Spontaneous Subarachnoid Hemorrhage"],"prefix":"10.1002","volume":"34","author":[{"given":"Bryan D.","family":"Lizza","sequence":"first","affiliation":[{"name":"Department of Pharmacy Northwestern Medicine Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Kosteva","sequence":"additional","affiliation":[{"name":"Department of Neurology Northwestern Memorial Faculty Foundation 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