{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T11:02:18Z","timestamp":1789124538758,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,10,14]],"date-time":"2014-10-14T00:00:00Z","timestamp":1413244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006259","name":"Teva Pharmaceutical Industries","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006259","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2014,12]]},"abstract":"\n Background<\/jats:title>\n \n The serotonin toxicity syndrome (\n STS<\/jats:styled-content>\n ) is a potential risk with concurrent use of the monoamine oxidase type\u2010B inhibitor rasagiline and antidepressants.\n <\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n \n To assess systematically the occurrence of\n STS<\/jats:styled-content>\n in patients with Parkinson disease (\n PD<\/jats:styled-content>\n ) treated with rasagiline plus antidepressants (R+\n ATD<\/jats:styled-content>\n ), rasagiline without antidepressants (R), or antidepressants plus anti\u2010\n PD<\/jats:styled-content>\n dopaminergic medications (\n ATD<\/jats:styled-content>\n ) other than either rasagiline or selegiline.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A phase\n IV<\/jats:styled-content>\n multicenter retrospective cohort study was conducted of patients with\n PD<\/jats:styled-content>\n who began receiving R+\n ATD<\/jats:styled-content>\n , R, or\n ATD<\/jats:styled-content>\n between September 1, 2006, and December 31, 2008. Medical records were reviewed for patient demographics, treatment details, and hospitalizations\/emergency department (\n ED<\/jats:styled-content>\n ) visits. An adjudication committee independently reviewed records to verify case ascertainment and used the Hunter Serotonin Toxicity Criteria for case definition. Outcome variables were analyzed by descriptive statistics.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 1504 patients with\n PD<\/jats:styled-content>\n (471 with R+\n ATD<\/jats:styled-content>\n ; 511 with R; and 525 with\n ATD<\/jats:styled-content>\n ) were enrolled from 37 sites. In the R+\n ATD<\/jats:styled-content>\n and\n ATD<\/jats:styled-content>\n groups, selective serotonin reuptake inhibitors (\n SSRI<\/jats:styled-content>\n s) were most frequently used (74.5% and 77%, respectively). In the R+\n ATD<\/jats:styled-content>\n and\n ATD<\/jats:styled-content>\n groups, mean duration of antidepressant use (tricyclic,\n SSRI<\/jats:styled-content>\n , and other) were 50.5\u201353.5\u00a0weeks and 51.7\u201380.9\u00a0weeks, respectively. Overall, 195 patients (13%) from all three groups had one or more hospitalization\/\n ED<\/jats:styled-content>\n visits. No cases of\n STS<\/jats:styled-content>\n were identified in any group.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n In this large multicenter retrospective cohort study, concurrent administration of R+ATD was not associated with\n STS<\/jats:styled-content>\n . The findings of this phase\n IV<\/jats:styled-content>\n study expand the drug interaction and pharmacovigilance safety awareness for the use of antidepressants in patients with\n PD<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/phar.1500","type":"journal-article","created":{"date-parts":[[2014,10,14]],"date-time":"2014-10-14T07:38:25Z","timestamp":1413272305000},"page":"1250-1258","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Serotonin Toxicity Association with Concomitant Antidepressants and Rasagiline Treatment: Retrospective Study (\n STACCATO<\/scp>\n )"],"prefix":"10.1002","volume":"34","author":[{"given":"Michel","family":"Panisset","sequence":"first","affiliation":[{"name":"H\u00f4pital Notre\u2010Dame du CHUM Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack J.","family":"Chen","sequence":"additional","affiliation":[{"name":"Loma Linda University Loma Linda California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean H.","family":"Rhyee","sequence":"additional","affiliation":[{"name":"University of Massachusetts Medical School Worcester Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill","family":"Conner","sequence":"additional","affiliation":[{"name":"Teva Neuroscience Inc. Kansas City Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Mathena","sequence":"additional","affiliation":[{"name":"Teva Neuroscience Inc. Kansas City Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the STACCATO study investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,10,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21803"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/phar.1314"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0079510"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23884"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2007.09.021"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2165\/11207560-000000000-00000"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.59.12.1937"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0809335"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)71083-7"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.62.2.241"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/00207454.2011.620193"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0091270010369674"},{"key":"e_1_2_6_14_1","volume-title":"Azilect [package insert]","year":"2009"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra041867"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1998.tb123399.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcg109"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0644(96)70116-6"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-013-9914-2"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-007-0811-8"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2009.08.014"},{"issue":"1","key":"e_1_2_6_22_1","first-page":"359","article-title":"Retrospective analysis of the incidence of serotonin toxicity in patients taking rasagiline and antidepressants in clinical trials","volume":"24","author":"Montgomery EB","year":"2009","journal-title":"Mov Disord"},{"issue":"2","key":"e_1_2_6_23_1","first-page":"S400","article-title":"The tolerability of rasagiline when used concurrently with serotonin reuptake inhibitors in Parkinson's disease: a retrospective analysis","volume":"25","author":"Ghosh P","year":"2010","journal-title":"Mov Disord"},{"issue":"4","key":"e_1_2_6_24_1","first-page":"A485","article-title":"A \u201creal world\u201d view of the tolerability of rasagiline with anti\u2010depressants in Parkinson's disease: a retrospective study","volume":"76","author":"Chhabria N","year":"2011","journal-title":"Neurology"},{"key":"e_1_2_6_25_1","unstructured":"World Medical Association.Declaration of Helsinki: ethical principles for medical research involving human subjects. 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