{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T11:44:58Z","timestamp":1777290298176,"version":"3.51.4"},"reference-count":15,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2014,12,17]],"date-time":"2014-12-17T00:00:00Z","timestamp":1418774400000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:sec>\n                    <jats:title>Study Objective<\/jats:title>\n                    <jats:p>To examine the impact of intravenous acetaminophen on the total quantity of opioids (in morphine equivalents) administered within the first 48\u00a0hours postoperatively and perioperatively, while still affording patients adequate analgesia, in women who underwent total abdominal hysterectomies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Retrospective chart review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Tertiary care community hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients<\/jats:title>\n                    <jats:p>One hundred women underwent total abdominal hysterectomies performed by a single surgeon: 50 patients received opioids only (fentanyl, morphine, hydromorphone, meperidine, or oxycodone), without the addition of any acetaminophen, between January 1 and March 28, 2011, and 50 patients received intravenous acetaminophen 1000\u00a0mg every 6\u00a0hours in addition to opioids (multimodal group) between May 1 and July 16, 2012 (time period coincided with the addition of intravenous acetaminophen to the hospital formulary). Patients in both groups were also given nonopioids (celecoxib, dexmedetomidine, aspirin, or tizanidine) perioperatively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>\n                      Patients in both groups had a mean age of 55\u00a0years (mean\u00a0\u00b1\u00a0\n                      <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\n                      55\u00a0\u00b1\u00a013\u00a0yrs in the multimodal group, 55\u00a0\u00b1\u00a015\u00a0yrs in the opioids\u2010only group), surgery time of ~2\u00a0hours (116\u00a0\u00b1\u00a051\u00a0min in the multimodal group, 118\u00a0\u00b1\u00a040\u00a0min in the opioids\u2010only group), and an anesthesia time of ~3.5\u00a0hours (209\u00a0\u00b1\u00a079\u00a0min in the multimodal group, 207\u00a0\u00b1\u00a079\u00a0min in the opioids\u2010only group). During postoperative days 1\u20132, intravenous acetaminophen reduced opioid use by 31% (mean\u00a0\u00b1\u00a0\n                      <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\n                      47\u00a0\u00b1\u00a024\u00a0mg in the multimodal group vs 68\u00a0\u00b1\u00a037\u00a0mg in the opioids\u2010only group, p=0.003) and by 26% during the total perioperative period, defined as preoperative, intraoperative, recovery room, and postoperative days 1\u20132 (73\u00a0\u00b1\u00a024\u00a0mg in the multimodal group vs 99\u00a0\u00b1\u00a039\u00a0mg in the opioids\u2010only group, p=0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The multimodal approach to perioperative analgesic management, which includes concurrent administration of intravenous acetaminophen and opioids, is effective in reducing the total average amount of opioids administered on postoperative days 1\u20132 and perioperatively. Limitations of this study include its short duration, retrospective design, and single\u2010site setting. These results may not be generalized to patients undergoing other types of obstetric\u2010gynecologic surgeries.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/phar.1513","type":"journal-article","created":{"date-parts":[[2014,12,21]],"date-time":"2014-12-21T11:29:51Z","timestamp":1419161391000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Impact of Intravenous Acetaminophen on Reducing Opioid Use After Hysterectomy"],"prefix":"10.1002","volume":"34","author":[{"given":"Brittany O.","family":"Herring","sequence":"first","affiliation":[{"name":"Pharmacy Department Memorial Regional Hospital Hollywood Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheila","family":"Ader","sequence":"additional","affiliation":[{"name":"Pharmacy Department Memorial Regional Hospital Hollywood Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angel","family":"Maldonado","sequence":"additional","affiliation":[{"name":"Pharmacy Department Memorial Regional Hospital Hollywood Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Hawkins","sequence":"additional","affiliation":[{"name":"Pharmacy Department Memorial Regional Hospital Hollywood Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaretta","family":"Kearson","sequence":"additional","affiliation":[{"name":"Pharmacy Department Memorial Regional Hospital Hollywood Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madeline","family":"Camejo","sequence":"additional","affiliation":[{"name":"Pharmacy Department Memorial Regional Hospital Hollywood Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,12,17]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"1347","article-title":"Management of common opioid\u2010induced adverse effect","volume":"74","author":"Swegle JM","year":"2006","journal-title":"Am Fam Physician"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2009.12.012"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2005.03.006"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1533-2500.2011.00476.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000177099.28914.A7"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1533-2500.2010.00426.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e31823c1030"},{"key":"e_1_2_7_9_1","volume-title":"Hysterectomy","author":"Calderon M","year":"2012"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmwh.2004.08.021"},{"key":"e_1_2_7_11_1","volume-title":"Ofirmev (acetaminophen intravenous) package insert","author":"Cadence Pharmaceuticals","year":"2010"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2010.12.011"},{"key":"e_1_2_7_13_1","unstructured":"GlobalRPh.Opioids \u2013 equianalgesic dosages. 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