{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T08:59:34Z","timestamp":1767085174677,"version":"build-2065373602"},"reference-count":13,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,6,10]],"date-time":"2015-06-10T00:00:00Z","timestamp":1433894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:p>\n                    Apixaban, a direct factor Xa inhibitor, is a novel oral anticoagulant (\n                    <jats:styled-content style=\"fixed-case\">NOAC<\/jats:styled-content>\n                    ) indicated for prevention of embolic events in patients with nonvalvular atrial fibrillation. The agent is associated with a lower risk of bleeding compared with vitamin K antagonists such as warfarin. Hemopericardium is a life\u2010threatening bleeding event that is rarely caused by anticoagulants. We describe the case of a 76\u2010year\u2010old woman who was diagnosed with nonvalvular atrial fibrillation and treated with apixaban. Six weeks later, she was hospitalized after complaints of weakness and dizziness, and a chest radiograph revealed cardiomegaly. Further imaging, including a computed tomography scan and transthoracic echocardiogram, confirmed a diagnosis of hemopericardium. To our knowledge, this is the first case report of hemopericardium associated with apixaban therapy. This report, along with two previous cases reports of hemopericardium associated with dabigatran and rivaroxaban, emphasizes the need for careful use of\n                    <jats:styled-content style=\"fixed-case\">NOAC<\/jats:styled-content>\n                    s and for further research to identify an antidote or other method for controlling hemorrhage secondary to\n                    <jats:styled-content style=\"fixed-case\">NOAC<\/jats:styled-content>\n                    s in an acute setting. Furthermore, clinicians should consider hemopericardium in the differential diagnosis of patients treated with anticoagulants, including\n                    <jats:styled-content style=\"fixed-case\">NOAC<\/jats:styled-content>\n                    s, who present with cardiomegaly.\n                  <\/jats:p>","DOI":"10.1002\/phar.1602","type":"journal-article","created":{"date-parts":[[2015,6,19]],"date-time":"2015-06-19T07:45:37Z","timestamp":1434699937000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Spontaneous Hemopericardium in a Patient Receiving Apixaban Therapy: First Case Report"],"prefix":"10.1002","volume":"35","author":[{"given":"Chen","family":"Sigawy","sequence":"first","affiliation":[{"name":"Internal Medicine D The Chaim Sheba Medical Center Tel\u2010Hashomer Israel"},{"name":"affiliated with Sackler Faculty of Medicine Tel\u2010Aviv University Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Apter","sequence":"additional","affiliation":[{"name":"affiliated with Sackler Faculty of Medicine Tel\u2010Aviv University Israel"},{"name":"Radiology Department The Chaim Sheba Medical Center Tel\u2010Hashomer Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob","family":"Vine","sequence":"additional","affiliation":[{"name":"Internal Medicine D The Chaim Sheba Medical Center Tel\u2010Hashomer Israel"},{"name":"affiliated with Sackler Faculty of Medicine Tel\u2010Aviv University Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ehud","family":"Grossman","sequence":"additional","affiliation":[{"name":"Internal Medicine D The Chaim Sheba Medical Center Tel\u2010Hashomer Israel"},{"name":"affiliated with Sackler Faculty of Medicine Tel\u2010Aviv University Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,6,10]]},"reference":[{"key":"e_1_2_5_2_1","unstructured":"Bristol\u2010Myers Sc.Eliquis Highlights of Prescribing Information. 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