{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T18:35:37Z","timestamp":1769970937929,"version":"3.49.0"},"reference-count":10,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,8,3]],"date-time":"2015-08-03T00:00:00Z","timestamp":1438560000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:p>Levetiracetam is considered by many clinicians to be one of the most benign antiepileptic medications available. We report the case of a 24\u2010year\u2010old man presenting with seizures for which he was started on levetiracetam. Despite an extensive work\u2010up and treatment of possible infectious and noninfectious issues, the patient remained intermittently febrile. When a marked peripheral eosinophilia was noted, the patient's levetiracetam was discontinued and phenytoin prescribed. The fever resolved within 24\u00a0hours, and the patient's eosinophilia count returned to normal limits following discharge back to his long\u2010term care facility. We estimate the probability of this reaction related to levetiracetam as probable based on a score of 7 on the Naranjo scale. Clinicians should be aware of the possibility that levetiracetam may be an offending agent in a patient with unexplained fever and eosinophilia. These may be early signs of the progression to a more serious drug hypersensitivity reaction, such as drug rash, eosinophilia, and systemic symptoms (<jats:styled-content style=\"fixed-case\">DRESS<\/jats:styled-content>) syndrome.<\/jats:p>","DOI":"10.1002\/phar.1617","type":"journal-article","created":{"date-parts":[[2015,8,3]],"date-time":"2015-08-03T05:26:09Z","timestamp":1438579569000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Eosinophilia and Fever with Levetiracetam: A Case Report"],"prefix":"10.1002","volume":"35","author":[{"given":"Alexander H.","family":"Flannery","sequence":"first","affiliation":[{"name":"Department of Pharmacy Services University of Kentucky HealthCare Lexington Kentucky"},{"name":"Department of Pharmacy Practice and Science University of Kentucky College of Pharmacy Lexington Kentucky"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria D.","family":"Willey","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care, and Sleep Medicine University of Kentucky College of Medicine Lexington Kentucky"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa L.","family":"Thompson Bastin","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Services University of Kentucky HealthCare Lexington Kentucky"},{"name":"Department of Pharmacy Practice and Science University of Kentucky College of Pharmacy Lexington Kentucky"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ketan P.","family":"Buch","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care, and Sleep Medicine University of Kentucky College of Medicine Lexington Kentucky"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric S.","family":"Bensadoun","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care, and Sleep Medicine University of Kentucky College of Medicine Lexington Kentucky"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,8,3]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.2165\/11208340-000000000-00000"},{"key":"e_1_2_5_3_1","volume-title":"Keppra (levetiracetam) package insert","author":"UCB, Inc.","year":"2009"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S2937"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1665-2681(19)31663-1"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1R084"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-7-2"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1085-5629(96)80038-1"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000069956"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e3181a4d1a1"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"}],"container-title":["Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fphar.1617","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fphar.1617","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/phar.1617","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:11:59Z","timestamp":1761059519000},"score":1,"resource":{"primary":{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/10.1002\/phar.1617"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":10,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.1002\/phar.1617"],"URL":"https:\/\/doi.org\/10.1002\/phar.1617","archive":["Portico"],"relation":{},"ISSN":["0277-0008","1875-9114"],"issn-type":[{"value":"0277-0008","type":"print"},{"value":"1875-9114","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8]]},"assertion":[{"value":"2015-08-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}