{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T22:07:08Z","timestamp":1790546828742,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,9,25]],"date-time":"2015-09-25T00:00:00Z","timestamp":1443139200000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:sec><jats:label\/><jats:p>Several nonpharmacologic strategies for orthostatic hypotension exist including avoiding large carbohydrate\u2010rich meals; limiting alcohol consumption; maintaining adequate hydration; adding salt to foods; and using compression stockings, tilt\u2010table exercises, or abdominal binders. If these fail, however, only limited evidence\u2010based pharmacologic treatment options are available including the use of fludrocortisone, midodrine, pyridostigmine, and droxidopa as well as pseudoephedrine, ocetreotide, and atomoxetine. This report discusses a case of atomoxetine use for 10\u00a0weeks in an elderly patient with primary orthostatic hypotension. An 84\u2010year\u2010old man with long\u2010standing primary orthostatic hypotension presented to our ambulatory cardiology pharmacotherapy clinic after several unsuccessful pharmacologic therapies including fludrocortisone, midodrine, and pyridostigmine. Nonpharmacologic strategies were also implemented. Atomoxetine was initiated, and the patient showed gradual improvements in symptoms and blood pressure control over the course of 10\u00a0weeks. Our data suggest that low\u2010dose atomoxetine is an effective and safe agent for symptom improvement and blood pressure control in elderly patients with primary orthostatic hypotension.<\/jats:p><\/jats:sec>","DOI":"10.1002\/phar.1635","type":"journal-article","created":{"date-parts":[[2015,9,25]],"date-time":"2015-09-25T14:57:56Z","timestamp":1443193076000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Atomoxetine for Orthostatic Hypotension in an Elderly Patient Over 10 Weeks: A Case Report"],"prefix":"10.1002","volume":"35","author":[{"given":"Genevieve M.","family":"Hale","sequence":"first","affiliation":[{"name":"Assistant Professor Nova Southeastern University College of Pharmacy Palm Beach Gardens Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Brenner","sequence":"additional","affiliation":[{"name":"Clinical Pharmacy Specialist\u2013Cardiology VA Ann Arbor Healthcare System Ann Arbor Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-011-0119-5"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.12062"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp329"},{"key":"e_1_2_6_5_1","first-page":"35","article-title":"Prevalence, associations, and risk factors for orthostatic hypotension in medical, surgical, and trauma inpatients: an observational cohort study","volume":"12","author":"Aung AK","year":"2012","journal-title":"Ochsner J"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.19.6.508"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.29.4.424"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.32.2.298"},{"key":"e_1_2_6_9_1","first-page":"527","article-title":"Evaluation and management of orthostatic hypotension","volume":"84","author":"Lanier JB","year":"2011","journal-title":"Am Fam Physician"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp074189"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2006.01512.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(02)01025-2"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70088-7"},{"key":"e_1_2_6_14_1","volume-title":"Practice of geriatrics","author":"Duthie EH","year":"2007"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.06.052"},{"key":"e_1_2_6_16_1","volume-title":"Neurology in clinical practice","author":"Bradley WG","year":"2008"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2007.02.023"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.1.120"},{"key":"e_1_2_6_19_1","unstructured":"U.S. Food and Drug Administration.Drug safety and availability: Midodrine update September 2010. Available fromhttp:\/\/www.fda.gov\/Drugs\/DrugSafety\/ucm225444.htm. Accessed May 30 2015."},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.63.4.noc50340"},{"key":"e_1_2_6_21_1","unstructured":"U.S. Food and Drug Administration.FDA news release: FDA approves Northera to treat neurogenic orthostatic hypotension February 18 2014.\u00a0Available fromhttp:\/\/www.fda.gov\/NewsEvents\/Newsroom\/PressAnnouncements\/ucm386311.htm. 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