{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T22:18:16Z","timestamp":1789942696576,"version":"4.0.1"},"reference-count":11,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,1,9]],"date-time":"2016-01-09T00:00:00Z","timestamp":1452297600000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p>The interleukin\u20101 (IL\u20101) family consists of 11 cytokines that play key regulatory roles in many immune and inflammatory processes. Anakinra (Kineret, Amgen, Inc.) is an IL\u20101 receptor antagonist (IL\u20101ra). Increased levels of IL\u20101 are found in several disease states suggesting that anakinra may be beneficial in disorders associated with elevated IL\u20101 levels. Anakinra has been effectively used in the treatment of systemic juvenile idiopathic arthritis and adult\u2010onset Still's disease (AOSD). Despite its therapeutic benefits, anakinra also has potential side effects, including hepatotoxicity. We present a case of AOSD in an adolescent male that was treated with anakinra. During treatment, the patient developed acute liver failure that resolved upon withdrawal of anakinra. Although anakinra\u2010induced liver injury has been reported in adults, including one case of subacute liver failure, we believe our case is the first to show severe acute liver failure in an adolescent treated with anakinra. This case provides significant insight into a potentially serious complication associated with anakinra. It is important to further delineate these complications as the treatment indications for this drug expand.<\/jats:p>","DOI":"10.1002\/phar.1677","type":"journal-article","created":{"date-parts":[[2016,1,10]],"date-time":"2016-01-10T14:16:38Z","timestamp":1452435398000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Anakinra\u2010Induced Acute Liver Failure in an Adolescent Patient with Still's Disease"],"prefix":"10.1002","volume":"36","author":[{"given":"Sarah A.","family":"Taylor","sequence":"first","affiliation":[{"name":"Lurie Children's Hospital of Chicago Chicago Illinois"},{"name":"Columbia University Medical Center New York New\u00a0York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer M.","family":"Vittorio","sequence":"additional","affiliation":[{"name":"Columbia University Medical Center New York New\u00a0York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Martinez","sequence":"additional","affiliation":[{"name":"Columbia University Medical Center New York New\u00a0York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith A.","family":"Fester","sequence":"additional","affiliation":[{"name":"Columbia University Medical Center New York New\u00a0York"},{"name":"Barnes\u2010Jewish Hospital St Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen M.","family":"Lagana","sequence":"additional","affiliation":[{"name":"Columbia University Medical Center New York New\u00a0York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven J.","family":"Lobritto","sequence":"additional","affiliation":[{"name":"Columbia University Medical Center New York New\u00a0York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Ovchinsky","sequence":"additional","affiliation":[{"name":"Columbia University Medical Center New York New\u00a0York"},{"name":"Children's Hospital at Montefiore Bronx New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,1,9]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-137-12-200212170-00007"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1546-0096-7-21"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S23920"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.revmed.2012.10.372"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.121309"},{"key":"e_1_2_5_7_1","first-page":"844","article-title":"Still Disease and the Liver \u2013 an Underappreciated Association","volume":"12","author":"Lim KBL","year":"2011","journal-title":"Gastroenterol Hepatol (N Y)"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03261961"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-007-0791-y"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025442"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0041392"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2012.02.014"}],"container-title":["Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fphar.1677","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fphar.1677","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/phar.1677","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T10:26:51Z","timestamp":1761042411000},"score":1,"resource":{"primary":{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/10.1002\/phar.1677"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1002\/phar.1677"],"URL":"https:\/\/doi.org\/10.1002\/phar.1677","archive":["Portico"],"relation":{},"ISSN":["0277-0008","1875-9114"],"issn-type":[{"value":"0277-0008","type":"print"},{"value":"1875-9114","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"2016-01-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}