{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T07:55:55Z","timestamp":1788508555781,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,2,5]],"date-time":"2016-02-05T00:00:00Z","timestamp":1454630400000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:p>Amiodarone remains the mostly frequently used antiarrhythmic in clinical practice and is most often used to maintain normal sinus rhythm in patients with atrial fibrillation who have failed a rate control strategy. Amiodarone has superior efficacy over other antiarrhythmics, a lower risk of torsade de pointes, and a better cardiovascular safety profile in patients with structural heart disease. However, amiodarone is associated with notable noncardiac toxicities affecting the thyroid, lungs, eyes, liver, and central nervous system. Since 2000, clinicians have been advised to follow amiodarone monitoring guidelines provided by the Heart Rhythm Society. Adherence to these recommendations in clinical practice, however, is suboptimal. Pharmacists play a major role in ensuring the safe and effective use of medications, particularly high\u2010risk medications such as amiodarone. This qualitative review details the evidence supporting the role of pharmacist\u2010led amiodarone monitoring services (<jats:styled-content style=\"fixed-case\">AMS<\/jats:styled-content>) in improving adherence to amiodarone monitoring guidelines and identifying adverse effects. Five studies were identified, and, overall, these programs had a favorable impact on improving adherence to guideline\u2010recommended monitoring standards for amiodarone. The available evidence is limited by the significant variations in study designs and outcome definitions, lack of patient randomization, and limited generalizability. Nevertheless, available studies suggest that pharmacist\u2010led <jats:styled-content style=\"fixed-case\">AMS<\/jats:styled-content> may improve adherence to recommended monitoring guidelines and identification of amiodarone\u2010related adverse effects. Further study is warranted to demonstrate whether these services impact the overall quality of care provided to patients receiving amiodarone, which may justify broader implementation.<\/jats:p>","DOI":"10.1002\/phar.1697","type":"journal-article","created":{"date-parts":[[2016,2,5]],"date-time":"2016-02-05T02:27:05Z","timestamp":1454639225000},"page":"230-236","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Effectiveness of Pharmacist\u2010Led Amiodarone Monitoring Services on Improving Adherence to Amiodarone Monitoring Recommendations: A Systematic Review"],"prefix":"10.1002","volume":"36","author":[{"given":"Dave L.","family":"Dixon","sequence":"first","affiliation":[{"name":"Department of Pharmacotherapy &amp; Outcomes Science Virginia Commonwealth University School of Pharmacy Richmond Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven P.","family":"Dunn","sequence":"additional","affiliation":[{"name":"Heart &amp; Vascular Department of Pharmacy Services University of Virginia Health System Charlottesville Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Kelly","sequence":"additional","affiliation":[{"name":"PGY\u20102 Ambulatory Care \u2013 Family Medicine Pharmacy Resident University of Colorado Skaggs School of Pharmacy &amp; Pharmaceutical Sciences Aurora Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy R.","family":"McLlarky","sequence":"additional","affiliation":[{"name":"Chippenham Hospital Richmond Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy E.","family":"Brown","sequence":"additional","affiliation":[{"name":"Virginia Commonwealth University Richmond Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,2,5]]},"reference":[{"issue":"4","key":"e_1_2_6_2_1","first-page":"e29","article-title":"Heart disease and stroke statistics\u20142015 update: a report from the American Heart Association","volume":"131","author":"Mozaffarian D","year":"2015","journal-title":"Circulation"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.03.021"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2010.01950.x"},{"key":"e_1_2_6_5_1","unstructured":"IMF Health.National prescription audit\u2122: 2006\u20132010. 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