{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T16:40:50Z","timestamp":1761064850233,"version":"build-2065373602"},"reference-count":53,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,6,11]],"date-time":"2016-06-11T00:00:00Z","timestamp":1465603200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:p>Hypertension affects one\u2010third of all females in the United States, with the prevalence increasing over a female's lifespan. The approach to treating females with hypertension varies depending on a female's age, race, comorbidities, and whether she is of child\u2010bearing age or pregnant. It is important to factor in the safety and effectiveness of antihypertensive medications across these populations of females. Blood pressure target goals are the same in females as in males regardless of comorbidities or stage of life, with the exception of those females who are pregnant. Recommendations for antihypertensive medication do not differ between females and males based on disease state or stage of life, with the exception of females who are pregnant, breastfeeding, or of child\u2010bearing age. Multiple guidelines recommend avoiding renin\u2010angiotensin system blockers during pregnancy and suggest balancing the risk versus benefit in females of child\u2010bearing age. Further, multiple guidelines provide race\u2010based therapy recommendations for the use of calcium channel blockers and thiazide diuretics in black versus nonblack patients, irrespective of sex. Future research is needed to evaluate whether there are sex differences relative to blood pressure and cardiovascular event\u2010lowering relative to specific antihypertensive medications with a focus on pharmacogenomic differences.<\/jats:p>","DOI":"10.1002\/phar.1754","type":"journal-article","created":{"date-parts":[[2016,4,11]],"date-time":"2016-04-11T21:48:20Z","timestamp":1460411300000},"page":"638-651","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Antihypertensive Therapy in Females: A Clinical Review Across the Lifespan"],"prefix":"10.1002","volume":"36","author":[{"given":"Joel C.","family":"Marrs","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy Skaggs School of Pharmacy and Pharmaceutical Sciences University of Colorado Aurora Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela M.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy Skaggs School of Pharmacy and Pharmaceutical Sciences University of Colorado Aurora Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,6,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/circ.131.suppl_2.o29"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.656850"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.13.1595"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.12237"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.284427"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.10.1314-a"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.303587"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjh.0000431740.32696.cc"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn427"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv161"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200948030-00001"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.152892"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1592\/phco.20.3.140.34782"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004670050614"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e31821daaf6"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.7517"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc15-S004"},{"key":"e_1_2_8_19_1","first-page":"337","article-title":"KDIGO clinical practice guideline for the management of blood pressure in chronic kidney disease","volume":"2","author":"Kidney Disease: Improving Global Outcomes (KDIGO) Blood Pressure Work Group","year":"2012","journal-title":"Kidney Int"},{"issue":"5","key":"e_1_2_8_20_1","first-page":"1122","article-title":"Task force on hypertension in pregnancy. 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