{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:20:50Z","timestamp":1767831650731,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,6,15]],"date-time":"2016-06-15T00:00:00Z","timestamp":1465948800000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007926","name":"University of Oklahoma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007926","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec><jats:title>Study Objective<\/jats:title><jats:p>To determine if significant correlations exist between glomerular filtration rate (GFR) prediction equation values, derived by using the original Schwartz equation and the Chronic Kidney Disease in Children (CKiD) bedside equation with a 24\u2010hour urine creatinine clearance (Cl<jats:sub>cr<\/jats:sub>) value normalized to a body surface area of 1.73 m<jats:sup>2<\/jats:sup> in overweight and obese children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective analysis (20 patients) and retrospective analysis (43 patients).<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Pediatric inpatient ward and pediatric nephrology clinic at a comprehensive academic medical center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>Sixty\u2010three pediatric patients (aged 5\u201317 years), of whom 27 were overweight (body mass index [BMI] at the 85th percentile or higher) and 36 were not overweight (BMI lower than the 85th percentile [controls]) between 2007 and 2012.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Main Results<\/jats:title><jats:p>Data from the overweight patients were compared with nonoverweight controls. GFR values were calculated by using the original Schwartz equation and the CKiD bedside equation. Each patient's 24\u2010hour urine Cl<jats:sub>cr<\/jats:sub> value normalized to a body surface area of 1.73 m<jats:sup>2<\/jats:sup> served as the index value. A Pearson correlation coefficient model was used to determine association between the 24\u2010hour urine Cl<jats:sub>cr<\/jats:sub> value (index value) with the Schwartz and CKiD GFR estimations. Significant correlation was found to exist between the Schwartz and CKiD bedside GFR estimations relative to the 24\u2010hour urine Cl<jats:sub>cr<\/jats:sub> in the control subjects (r = 0.85, p&lt;0.0001, and r = 0.85, p&lt;0.0001, respectively). Significant correlation was also found to exist between the Schwartz and CKiD bedside GFR values with the 24\u2010hour urine Cl<jats:sub>cr<\/jats:sub> value in overweight subjects (r = 0.86, p&lt;0.0001, and r = 0.86, p&lt;0.0001, respectively). The Schwartz equation estimated average GFR 21.75 ml\/minute\/1.73 m<jats:sup>2<\/jats:sup> higher than 24\u2010hour urine Cl<jats:sub>cr<\/jats:sub> (p&lt;0.0001) in overweight children with a kidney disorder. The CKiD bedside GFR estimations were not significantly different compared with 24\u2010hour urine Cl<jats:sub>cr<\/jats:sub> values for the overweight group with kidney disorder (p=0.85).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The Schwartz and CKiD bedside estimations of GFR correlated with 24\u2010hour urine Cl<jats:sub>cr<\/jats:sub> values in both overweight and nonoverweight children. Compared with the Schwartz equation, which tended to overestimate renal function, the CKiD bedside equation appeared to approximate 24\u2010hour urine Cl<jats:sub>cr<\/jats:sub> more closely in overweight children with kidney disorder.<\/jats:p><\/jats:sec>","DOI":"10.1002\/phar.1763","type":"journal-article","created":{"date-parts":[[2016,5,3]],"date-time":"2016-05-03T08:24:25Z","timestamp":1462263865000},"page":"598-606","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Applicability of the Schwartz Equation and the Chronic Kidney Disease in Children Bedside Equation for Estimating Glomerular Filtration Rate in Overweight Children"],"prefix":"10.1002","volume":"36","author":[{"given":"Teresa V.","family":"Lewis","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Clinical and Administrative Sciences The University of Oklahoma Health Sciences Center Oklahoma City Oklahoma"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald L.","family":"Harrison","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Clinical and Administrative Sciences The University of Oklahoma Health Sciences Center Oklahoma City Oklahoma"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brooke L.","family":"Gildon","sequence":"additional","affiliation":[{"name":"Southwestern Oklahoma State University College of Pharmacy Weatherford Oklahoma"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra M.","family":"Carter","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Clinical and Administrative Sciences The University of Oklahoma Health Sciences Center Oklahoma City Oklahoma"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin A.","family":"Turman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics College of Medicine The University of Oklahoma Health Sciences Center Oklahoma City Oklahoma"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,6,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/17.7.1157"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00582.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-144-1-200601030-00006"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005060638"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.58.2.259"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.111.6.1416"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2008030287"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2005.0525144"},{"key":"e_1_2_6_10_1","first-page":"1","article-title":"Changes in terminology for childhood overweight and obesity","volume":"25","author":"Ogden CL","year":"2010","journal-title":"Natl Health Stat Report"},{"key":"e_1_2_6_11_1","unstructured":"BMI Percentile Calculator for Child and Teen. 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