{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T03:07:43Z","timestamp":1776136063154,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,7,21]],"date-time":"2016-07-21T00:00:00Z","timestamp":1469059200000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:p>States and the federal government are under growing pressure to legalize the use of cannabis products for medical purposes in the United States. Sixteen states have legalized (or decriminalized possession of) products high in cannabidiol (<jats:styled-content style=\"fixed-case\">CBD<\/jats:styled-content>) and with restricted \u2206<jats:sup>9<\/jats:sup>\u2010tetrahydrocannabinol (\u2206<jats:sup>9<\/jats:sup>\u2010<jats:styled-content style=\"fixed-case\">THC<\/jats:styled-content>) content. In most of these states, the intent is for use in refractory epileptic seizures in children, but in a few states, the indications are broader. This review provides an overview of the pharmacology and toxicology of <jats:styled-content style=\"fixed-case\">CBD<\/jats:styled-content>; summarizes some of the regulatory, safety, and cultural issues relevant to the further exploitation of its antiepileptic or other pharmacologic activities; and assesses the current status and prospects for clinical development of <jats:styled-content style=\"fixed-case\">CBD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CBD<\/jats:styled-content>\u2010rich preparations for medical use in the United States. Unlike \u0394<jats:sup>9<\/jats:sup>\u2010<jats:styled-content style=\"fixed-case\">THC<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> CBD<\/jats:styled-content> elicits its pharmacologic effects without exerting any significant intrinsic activity on the cannabinoid receptors, whose activation results in the psychotropic effects characteristic of \u0394<jats:sup>9<\/jats:sup>\u2010<jats:styled-content style=\"fixed-case\">THC<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">CBD<\/jats:styled-content> possesses several pharmacologic activities that give it a high potential for therapeutic use. <jats:styled-content style=\"fixed-case\">CBD<\/jats:styled-content> exhibits neuroprotective, antiepileptic, anxiolytic, antipsychotic, and antiinflammatory properties. In combination with \u0394<jats:sup>9<\/jats:sup>\u2010<jats:styled-content style=\"fixed-case\">THC<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> CBD<\/jats:styled-content> has received regulatory approvals in several European countries and is currently under study in trials registered by the U.S. Food and Drug Administration in the United States. A number of states have passed legislation to allow for the use of <jats:styled-content style=\"fixed-case\">CBD<\/jats:styled-content>\u2010rich, limited \u0394<jats:sup>9<\/jats:sup>\u2010<jats:styled-content style=\"fixed-case\">THC<\/jats:styled-content>\u2013content preparations of cannabis for certain pathologic conditions. <jats:styled-content style=\"fixed-case\">CBD<\/jats:styled-content> is currently being studied in several clinical trials and is at different stages of clinical development for various medical indications. Judging from clinical findings reported so far, <jats:styled-content style=\"fixed-case\">CBD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CBD<\/jats:styled-content>\u2010enriched preparations have great potential utility, but uncertainties regarding sourcing, long\u2010term safety, abuse potential, and regulatory dilemmas remain.<\/jats:p>","DOI":"10.1002\/phar.1780","type":"journal-article","created":{"date-parts":[[2016,6,10]],"date-time":"2016-06-10T14:26:23Z","timestamp":1465568783000},"page":"781-796","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":123,"title":["Current Status and Prospects for Cannabidiol Preparations as New Therapeutic Agents"],"prefix":"10.1002","volume":"36","author":[{"given":"Pius S.","family":"Fasinu","sequence":"first","affiliation":[{"name":"The National Center for Natural Products Research School of Pharmacy The University of Mississippi University 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