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The disease occurs late in pregnancy or in the months following delivery, resulting in reduced systolic function and heart failure (<jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content>) symptoms. Limited direction is provided for the management of <jats:styled-content style=\"fixed-case\">PPCM<\/jats:styled-content>, and the safe and effective use of medications in pregnant and breastfeeding women with <jats:styled-content style=\"fixed-case\">PPCM<\/jats:styled-content> presents a unique challenge. Although several <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content> therapies in pregnant and lactating women are supported by robust evidence, evidence to support the use of other therapies is significantly lacking. Current guidelines recommend treatment as in other forms of <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content> with reduced left ventricular ejection fraction (<jats:styled-content style=\"fixed-case\">LVEF<\/jats:styled-content>) but with consideration for the important nuances in this population as well as the unique and potential teratogenic effects of these therapies. Since most patients with <jats:styled-content style=\"fixed-case\">PPCM<\/jats:styled-content> recover their <jats:styled-content style=\"fixed-case\">LVEF<\/jats:styled-content>, the duration of therapy is currently unknown and warrants further study. We review the available literature surrounding pharmacologic and device therapy for <jats:styled-content style=\"fixed-case\">PPCM<\/jats:styled-content> and provide insight into managing patients with the condition.<\/jats:p>","DOI":"10.1002\/phar.1795","type":"journal-article","created":{"date-parts":[[2016,7,4]],"date-time":"2016-07-04T02:03:07Z","timestamp":1467597787000},"page":"955-970","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Safe and Effective Use of Pharmacologic and Device Therapy for Peripartum Cardiomyopathy"],"prefix":"10.1002","volume":"36","author":[{"given":"Benjamin","family":"Laliberte","sequence":"first","affiliation":[{"name":"Department of Pharmacy Practice and Science University of Maryland School of Pharmacy Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brent N.","family":"Reed","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice and Science University of Maryland School of Pharmacy Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayesha","family":"Ather","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice and Science University of Maryland School of Pharmacy Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep","family":"Devabhakthuni","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice and Science University of Maryland School of Pharmacy Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Watson","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice and Science University of Maryland School of Pharmacy Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison B.","family":"Lardieri","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice and Science University of Maryland School of Pharmacy Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carissa M.","family":"Baker\u2010Smith","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Maryland School of Medicine Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,7,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfq120"},{"issue":"16","key":"e_1_2_10_3_1","first-page":"e240","article-title":"2013 ACCF\/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines","volume":"128","author":"Yancy CW","year":"2013","journal-title":"Circulation"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1505517"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.9.1183"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2015.01.004"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-013-0366-9"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.06.1309"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.08.717"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms16047644"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.81.3.922"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0086770"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu050"},{"key":"e_1_2_10_14_1","first-page":"72064","article-title":"Content and format of labeling for human prescription drug and biological products: requirements for pregnancy and lactation labeling","volume":"79","author":"Department of Health and Human Services","year":"2014","journal-title":"Fed Reg"},{"key":"e_1_2_10_15_1","volume-title":"Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk","author":"Briggs GG","year":"2011"},{"key":"e_1_2_10_16_1","unstructured":"Drugs and Lactation Database (LactMed).Bethesda (MD):National Library of Medicine (US);2016[updated monthly]. 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