{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T04:59:46Z","timestamp":1768885186437,"version":"3.49.0"},"reference-count":11,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,11,28]],"date-time":"2016-11-28T00:00:00Z","timestamp":1480291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:sec><jats:title>Study Objective<\/jats:title><jats:p>To evaluate the impact of continuous\u2010flow left ventricular assist device (<jats:styled-content style=\"fixed-case\">LVAD<\/jats:styled-content>) implantation on glycemic control in patients with type 2 diabetes mellitus and advanced chronic systolic heart failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective medical record review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Large academic tertiary and quaternary care hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>Eighty\u2010three adults with type 2 diabetes mellitus and advanced chronic systolic heart failure who underwent implantation of a continuous\u2010flow <jats:styled-content style=\"fixed-case\">LVAD<\/jats:styled-content> between July 1, 2008, and June 30, 2013.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements and Main Results<\/jats:title><jats:p>Baseline demographic data and laboratory values pertinent to glycemic control (hemoglobin A<jats:sub>1c<\/jats:sub> [A1C], total daily insulin requirements, noninsulin antidiabetic medication use, and body mass index [<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>]) were collected for each patient. Pre\u2010<jats:styled-content style=\"fixed-case\">LVAD<\/jats:styled-content> data were compared with data obtained during the 24 months after <jats:styled-content style=\"fixed-case\">LVAD<\/jats:styled-content> implantation. The mean age of the study population was 61.3 years, 70% were men, and 63% had ischemic cardiomyopathy. The first available mean \u00b1 <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> A1C after <jats:styled-content style=\"fixed-case\">LVAD<\/jats:styled-content> implantation was 6.21 \u00b1 1.5% at a median of 4.8 months (interquartile range 3.3\u20138.9), which represented a significant decrease from the pre\u2010<jats:styled-content style=\"fixed-case\">LVAD<\/jats:styled-content> A1C of 7.46 \u00b1 1.5% (p&lt;0.001). Average daily insulin requirements decreased by 22.9 units at the end of 24 months (p&lt;0.001). Over half of patients with prescriptions for noninsulin antidiabetic medications were able to discontinue therapy by the end of the study. Of note, <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> increased in the second year after <jats:styled-content style=\"fixed-case\">LVAD<\/jats:styled-content> implantation from a baseline of 32.3 kg\/m<jats:sup>2<\/jats:sup> to 34.9 kg\/m<jats:sup>2<\/jats:sup> (p=0.004). Regression analysis revealed that baseline A1C was the only independent predictor of change in A1C.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">LVAD<\/jats:styled-content> implantation was associated with a significant improvement in glycemic control. Further prospective studies are needed to evaluate the long\u2010term impact of <jats:styled-content style=\"fixed-case\">LVAD<\/jats:styled-content> implantation on the clinical course of diabetes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/phar.1853","type":"journal-article","created":{"date-parts":[[2016,10,25]],"date-time":"2016-10-25T11:27:01Z","timestamp":1477394821000},"page":"1210-1216","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Positive Impact of Continuous\u2010Flow Left Ventricular Assist Device Implantation on Glycemic Control in Patients with Type 2 Diabetes Mellitus and Advanced Chronic Systolic Heart Failure"],"prefix":"10.1002","volume":"36","author":[{"given":"Debbie C.","family":"Yen","sequence":"first","affiliation":[{"name":"Department of Pharmacy Duke University Hospital Durham North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mara H.","family":"Watson","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Duke University Hospital Durham North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindsey D.","family":"Burgess","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Duke University Hospital Durham North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maragatha","family":"Kuchibhatla","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Bioinformatics Duke University School of Medicine Durham North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chetan B.","family":"Patel","sequence":"additional","affiliation":[{"name":"Duke Heart Center Duke University Hospital Durham North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristen B.","family":"Campbell","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Duke University Hospital Durham North Carolina"},{"name":"Duke Heart Center Duke University Hospital Durham North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alyssa K.","family":"Vora","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Duke University Hospital Durham North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,11,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11897-009-0014-8"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hfc.2012.06.005"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn156"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-011-9257-z"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1532\/HSF98.2013323"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000000064"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfq204"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.166"},{"issue":"1","key":"e_1_2_6_10_1","first-page":"S6","article-title":"Standards of medical care in diabetes 2016","volume":"39","author":"Cefalu W","year":"2016","journal-title":"Diabetes Care"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-1727"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2012.09.024"}],"container-title":["Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fphar.1853","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fphar.1853","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/phar.1853","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T12:06:35Z","timestamp":1761048395000},"score":1,"resource":{"primary":{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/10.1002\/phar.1853"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,28]]},"references-count":11,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["10.1002\/phar.1853"],"URL":"https:\/\/doi.org\/10.1002\/phar.1853","archive":["Portico"],"relation":{},"ISSN":["0277-0008","1875-9114"],"issn-type":[{"value":"0277-0008","type":"print"},{"value":"1875-9114","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,28]]},"assertion":[{"value":"2016-11-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}