{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T16:06:10Z","timestamp":1783094770992,"version":"3.54.6"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,2,3]],"date-time":"2017-02-03T00:00:00Z","timestamp":1486080000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec><jats:title>Study Objective<\/jats:title><jats:p>To evaluate the odds of achieving viral suppression in <jats:styled-content style=\"fixed-case\">human immunodeficiency virus (HIV)<\/jats:styled-content> patients using antiretroviral therapy as a single\u2010tablet regimen (<jats:styled-content style=\"fixed-case\">STR<\/jats:styled-content>) or multiple\u2010tablet regimen (<jats:styled-content style=\"fixed-case\">MTR<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Sources<\/jats:title><jats:p>South Carolina Medicaid medical and pharmacy paid claims data were obtained from the South Carolina Revenue and Fiscal Affairs Office; laboratory data were obtained from the South Carolina Department of Health and Environmental Control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>A total of 1536 patients who were dispensed a complete <jats:styled-content style=\"fixed-case\">STR<\/jats:styled-content> (477 patients) or <jats:styled-content style=\"fixed-case\">MTR<\/jats:styled-content> (1059 patients) regimen lasting at least 60 days between January 1, 2006, and December 31, 2013.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements and Main Results<\/jats:title><jats:p>The analysis examined adherence levels and regimen type on odds of viral load suppression. Regimen adherence levels (90\u201394%, 85\u201389%, 80\u201384%, and less than 80%) were compared with the gold standard adherence for <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> of 95% or greater. Patients were followed from index date until the earliest date of regimen discontinuation, treatment switch, end of study period, last date of eligibility, or death. Differences in outcomes were evaluated by \u03c7<jats:sup>2<\/jats:sup>, Wilcoxon rank sum statistical tests, and multivariate regression models controlling for covariates. For <jats:styled-content style=\"fixed-case\">STR<\/jats:styled-content> regimens we find that, when compared with 95% or greater adherence, there is no statistical difference in the odds of viral suppression with adherence levels greater than or equal to 80%. However, adherence levels greater than or equal to 95% were associated with a greater odds of viral suppression when compared with less than 80% <jats:styled-content style=\"fixed-case\">STR<\/jats:styled-content> adherence (odds ratio [<jats:styled-content style=\"fixed-case\">OR]<\/jats:styled-content> 2.57, Dunnett 95% confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>] 1.04\u20136.32). For <jats:styled-content style=\"fixed-case\">MTR<\/jats:styled-content> regimens, there was no statistical difference in the odds of viral suppression for the adherence level 90\u201394% compared with the 95% or greater adherence (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 3.59, Dunnett 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.805\u201316.043). However, the 95% or greater adherence has greater odds of viral suppression compared with all other <jats:styled-content style=\"fixed-case\">MTR<\/jats:styled-content> adherence levels. In addition, no difference was found in the odds of viral suppression between <jats:styled-content style=\"fixed-case\">STR<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MTR<\/jats:styled-content> for all adherence levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Compared with 95% or greater adherence, <jats:styled-content style=\"fixed-case\">STR<\/jats:styled-content> regimens achieve viral suppression with adherence levels of 80% or greater, whereas <jats:styled-content style=\"fixed-case\">MTR<\/jats:styled-content> regimens require adherence levels of 90% or greater to achieve viral suppression in South Carolina Medicaid patients with <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">AIDS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/phar.1889","type":"journal-article","created":{"date-parts":[[2016,12,27]],"date-time":"2016-12-27T20:12:46Z","timestamp":1482869566000},"page":"204-213","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Odds of Viral Suppression by Single\u2010Tablet Regimens, Multiple\u2010Tablet Regimens, and Adherence Level in <scp>HIV<\/scp>\/<scp>AIDS<\/scp> Patients Receiving Antiretroviral Therapy"],"prefix":"10.1002","volume":"37","author":[{"given":"S. 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