{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T03:01:04Z","timestamp":1771556464207,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,7,2]],"date-time":"2017-07-02T00:00:00Z","timestamp":1498953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:p><jats:italic>Staphylococcus aureus<\/jats:italic> remains the most common causative pathogen in osteomyelitis. New or alternative therapies are often needed to treat <jats:italic>S. aureus<\/jats:italic> infections adequately in patients with drug allergies, treatment failures, or drug interactions. Oritavancin is a novel long\u2010acting lipoglycopeptide approved by the U.S. Food and Drug Administration in 2014 for the treatment of acute bacterial skin and skin structure infections. With a terminal half\u2010life of 8\u201310 days, oritavancin dosing regimens with infrequent parenteral administration now exist to treat infectious diseases such as osteomyelitis that would otherwise require daily dosing of intravenous antimicrobials for weeks; however, clinical experience is lacking. In this article, the first case of <jats:italic>S. aureus<\/jats:italic> osteomyelitis resulting from traumatic injury, successfully treated with oritavancin, is presented. Removal of the nail used for a comminuted tibial shaft fracture repair followed by a 6\u2010week treatment course with oritavancin resulted in clinical response.<\/jats:p>","DOI":"10.1002\/phar.1957","type":"journal-article","created":{"date-parts":[[2017,5,23]],"date-time":"2017-05-23T21:06:30Z","timestamp":1495573590000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Successful Treatment of Methicillin Susceptible <i>Staphylococcus aureus<\/i> Osteomyelitis with Oritavancin"],"prefix":"10.1002","volume":"37","author":[{"given":"Dino J.","family":"Delaportas","sequence":"first","affiliation":[{"name":"Infectious Diseases Division Mon Health Morgantown West Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandy J.","family":"Estrada","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Lee Health Fort Myers Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Darmelio","sequence":"additional","affiliation":[{"name":"Mountainstate Orthopedic Associates Morgantown West Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,7,2]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir842"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2010.01.005"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/653519"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu778"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1310422"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkp126"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkp286"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00766-08"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00231-09"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200948020-00002"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.2008\/000588-0"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr329"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.04550-14"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00981-15"},{"key":"e_1_2_4_16_1","first-page":"407","article-title":"Bone tissue and plasma concentrations of linezolid and vancomycin in rabbits with prosthesis\u2010related infection due to MRSA","volume":"64","author":"Swoboda S","year":"2009","journal-title":"Pharmazie"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00020-07"},{"key":"e_1_2_4_18_1","doi-asserted-by":"crossref","first-page":"2830","DOI":"10.1128\/AAC.42.11.2830","article-title":"Efficacy of teicoplanin and autoradiographic diffusion pattern of [14C]teicoplanin in experimental Staphylococcus aureus infection of joint prostheses","volume":"42","author":"Saleh Mghir A","year":"1998","journal-title":"Antimicrob Agents Chemother"},{"key":"e_1_2_4_19_1","unstructured":"Medicines Company.Orbactiv (oritavancin) for injection [package insert].Parsippany NJ;2016."}],"container-title":["Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fphar.1957","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/phar.1957","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T11:53:13Z","timestamp":1761047593000},"score":1,"resource":{"primary":{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/10.1002\/phar.1957"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,2]]},"references-count":18,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1002\/phar.1957"],"URL":"https:\/\/doi.org\/10.1002\/phar.1957","archive":["Portico"],"relation":{},"ISSN":["0277-0008","1875-9114"],"issn-type":[{"value":"0277-0008","type":"print"},{"value":"1875-9114","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,2]]},"assertion":[{"value":"2017-07-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}