{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:23:39Z","timestamp":1779927819491,"version":"3.53.1"},"reference-count":16,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T00:00:00Z","timestamp":1559779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["1UL1TR001079"],"award-info":[{"award-number":["1UL1TR001079"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:sec><jats:title>Study Objective<\/jats:title><jats:p>Newly diagnosed pediatric patients with type 1 diabetes mellitus (T1D) can be underweight, overweight, or normal weight at presentation. Study objectives were to determine if, across weight categories, admission body weight (<jats:styled-content style=\"fixed-case\">ABW<\/jats:styled-content>)\u2010based initial insulin glargine dosing resulted in similar fasting blood glucose responses on day of discharge, how initial <jats:styled-content style=\"fixed-case\">ABW<\/jats:styled-content>\u2010based doses differed from doses at outpatient follow\u2010up, and whether an ideal body weight (<jats:styled-content style=\"fixed-case\">IBW<\/jats:styled-content>) would provide a better estimate of body weight after discharge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective chart review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Urban tertiary academic medical center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>Eighty\u2010one pediatric patients newly diagnosed with T1D who started therapy with subcutaneous insulin glargine between October 2014 and October 2016; patients were categorized by weight using body mass index (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>) percentiles (underweight, normal weight, or overweight\/obese).<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements and Main Results<\/jats:title><jats:p>Data on patient parameters from hospitalization to outpatient physician follow\u2010up were collected. The McLaren, Moore, and <jats:styled-content style=\"fixed-case\">BMI IBW<\/jats:styled-content> methods were used to calculate <jats:styled-content style=\"fixed-case\">IBW<\/jats:styled-content> for each patient; these <jats:styled-content style=\"fixed-case\">IBW<\/jats:styled-content>s were compared with weights at outpatient follow\u2010up. Initial insulin glargine doses were similar among all weight groups: median (range) 0.299 (0.227\u20130.4), 0.297 (0.204\u20130.421), and 0.291 (0.194\u20130.394) units\/kg\/dose, respectively, for the underweight, normal weight, and overweight\/obese groups. No significant differences in discharge fasting glucose level or insulin glargine dose change from admission to first outpatient follow\u2010up visit were noted. Underweight patients gained significantly more weight within 60\u00a0days after discharge compared with normal and overweight\/obese patients, (median 16.3% vs 7.7% and 5.7%, respectively; p=0.002), aligning closest with the McLaren <jats:styled-content style=\"fixed-case\">IBW<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">ABW<\/jats:styled-content> was the best estimate of weight at outpatient follow\u2010up in the overweight\/obese patient group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>For children who presented underweight, the McLaren <jats:styled-content style=\"fixed-case\">IBW<\/jats:styled-content> method was the best predictor of outpatient dose and body weight, whereas <jats:styled-content style=\"fixed-case\">ABW<\/jats:styled-content> was the best estimate in overweight and obese patients. Further investigation of the role of <jats:styled-content style=\"fixed-case\">IBW\u2010<\/jats:styled-content> or ABW\u2010based dosing methods in underweight pediatric patients with T1D may assist in optimal dosing.<\/jats:p><\/jats:sec>","DOI":"10.1002\/phar.2281","type":"journal-article","created":{"date-parts":[[2019,5,18]],"date-time":"2019-05-18T09:57:57Z","timestamp":1558173477000},"page":"741-748","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Insulin Glargine Dose and Weight Changes in Underweight, Normal Weight, and Overweight Children Newly Diagnosed with Type 1 Diabetes Mellitus"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1134-8657","authenticated-orcid":false,"given":"Bethany Sharpless","family":"Chalk","sequence":"first","affiliation":[{"name":"Department of Pharmacy The Johns Hopkins Hospital Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Crane","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Johns Hopkins University School of Medicine Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gayane","family":"Yenokyan","sequence":"additional","affiliation":[{"name":"Johns Hopkins Biostatistics Center Johns Hopkins Bloomberg School of Public Health Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika May","family":"Pineda","sequence":"additional","affiliation":[{"name":"University of Maryland School of Pharmacy Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlton K.K.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The Johns Hopkins Hospital Baltimore Maryland"},{"name":"Department of Pediatrics Johns Hopkins University School of Medicine Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/dci18-0023"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc18-0935"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.12337"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-07-0904"},{"key":"e_1_2_7_6_1","unstructured":"Statistics About Diabetes. 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