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Reactivation of hepatitis B implies a sudden increase in viral replication in a patient with chronic HBV infection or prior HBV exposure. Hepatitis B virus reactivation (HBVr) can occur spontaneously, but it is more commonly triggered by immunosuppressive therapies for cancer, immunologic diseases, or transplantation. Elimination of hepatitis C virus (HCV) in HBV\u2010HCV coinfected individuals treated with direct\u2010acting antivirals (DAAs) has also been identified as an important cause of HBVr. Hepatitis B virus reactivation is an underappreciated but important complication of common medical therapies that can delay treatment or result in clinical episodes of hepatitis, hepatic failure, or death. In this review, factors associated with HBVr, particularly medication\u2010related risks, are explored. We review data involving rituximab and ofatumumab, doxorubicin, corticosteroids, tumor necrosis factor antagonists, tyrosine kinases, bortezomib, hematologic stem cell transplantation, and DAAs for HCV treatment. In addition, we discuss screening strategies, choice of antiviral prophylaxis, and the optimal duration of therapy for HBVr. With additional awareness, screening, and appropriate antiviral therapy, it is expected that most cases of HBVr can be prevented.<\/jats:p>","DOI":"10.1002\/phar.2340","type":"journal-article","created":{"date-parts":[[2019,10,9]],"date-time":"2019-10-09T13:59:52Z","timestamp":1570629592000},"page":"1190-1203","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":97,"title":["Hepatitis B Virus Reactivation: Risk Factors and Current Management Strategies"],"prefix":"10.1002","volume":"39","author":[{"given":"Danielle J.","family":"Smalls","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy and Outcomes Sciences University of South Carolina College of Pharmacy Columbia South Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reagan E.","family":"Kiger","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy and Outcomes Sciences University of South Carolina College of Pharmacy Columbia South Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7656-1259","authenticated-orcid":false,"given":"LeAnn B.","family":"Norris","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy and Outcomes Sciences University of South Carolina College of Pharmacy Columbia South Carolina"},{"name":"South Carolina Center of Economic Excellence for Medication Safety University of South Carolina College of Pharmacy Columbia South Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles L.","family":"Bennett","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy and Outcomes Sciences University of South Carolina College of Pharmacy Columbia South Carolina"},{"name":"South Carolina Center of Economic Excellence for Medication Safety University of South Carolina College of Pharmacy Columbia South Carolina"},{"name":"William Jennings Bryan Dorn VA Medical Center Columbia South Carolina"},{"name":"Arnold School of Public Health University of South Carolina Columbia South Carolina"},{"name":"Hollings Cancer Center Medical University of South Carolina Charleston South Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9221-9143","authenticated-orcid":false,"given":"Bryan L.","family":"Love","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy and Outcomes Sciences University of South Carolina College of Pharmacy Columbia South Carolina"},{"name":"South Carolina Center of Economic Excellence for Medication Safety University of South Carolina College of Pharmacy Columbia South Carolina"},{"name":"William Jennings Bryan Dorn VA Medical Center Columbia South Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i35.12462"},{"key":"e_1_2_8_3_1","volume-title":"Hepatitis B"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00052935"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.rr6701a1"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23190"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28156"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cld.728"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2014.1.576"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-004-0899-y"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22106"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2016.0024"},{"key":"e_1_2_8_13_1","first-page":"370","article-title":"EASL 2017 clinical practice guidelines on the management of hepatitis B virus infection","volume":"2","author":"European Association for the Study of the Liver. 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