{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:02:08Z","timestamp":1791820928738,"version":"4.3.4"},"reference-count":2,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,3,29]],"date-time":"2020-03-29T00:00:00Z","timestamp":1585440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Recent vancomycin PK\/PD and toxicodynamic studies enable a reassessment of the current dosing and monitoring guideline in an attempt to further optimize the efficacy and safety of vancomycin therapy. The area\u2010under\u2010the\u2010curve to minimum inhibitory concentration (AUC\/MIC) has been identified as the most appropriate pharmacokinetic\/pharmacodynamic (PK\/PD) target for vancomycin. The 2009 vancomycin consenus guidelines recommended specific trough concentrations as a surrogate marker for AUC\/MIC. However, more recent toxicodynamic studies have reported an increase in nephrotoxicity associated with trough monitoring.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>This is the executive summary of the new vancomycin consensus guidelines for dosing and monitoring vancomycin therapy and was developed by the American Society of Health\u2010Systems Pharmacists, Infectious Diseases Society of America, Pediatric Infectious Diseases Society and the Society of Infectious Diseases Pharmacists vancomycin consensus guidelines committee.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The recommendations provided in this document are intended to assist the clinician in optimizing vancomycin for the treatment of invasive MRSA infections in adult and pediatric patients. An AUC\/MIC by broth microdilution (BMD) ratio of 400 to 600 (assuming MICBMD of 1 mg\/L) should be advocated as the target to achieve clinical efficacy while improving patient safety for patients with serious MRSA infections. In such cases, AUC\u2010guided dosing and monitoring is the most accurate and optimal way to manage vancomycin therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/phar.2376","type":"journal-article","created":{"date-parts":[[2020,3,29]],"date-time":"2020-03-29T21:18:25Z","timestamp":1585516705000},"page":"363-367","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":81,"title":["Executive Summary: Therapeutic Monitoring of Vancomycin for Serious Methicillin\u2010Resistant\n                    <i>Staphylococcus aureus<\/i>\n                    Infections: A Revised Consensus Guideline and Review of the American Society of Health\u2010System Pharmacists, the Infectious Diseases Society of America, the Pediatric Infectious Diseases Society, and the Society of Infectious Diseases Pharmacists"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2220-0081","authenticated-orcid":false,"given":"Michael J.","family":"Rybak","sequence":"first","affiliation":[{"name":"Anti\u2010Infective Research Laboratory Department of Pharmacy Practice Eugene Applebaum College of Pharmacy &amp; Health Sciences Wayne State University Detroit Michigan"},{"name":"School of Medicine Wayne State University Detroit Michigan United States"},{"name":"Detroit Receiving Hospital Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6692-0884","authenticated-orcid":false,"given":"Jennifer","family":"Le","sequence":"additional","affiliation":[{"name":"Skaggs School of Pharmacy and Pharmaceutical Sciences University of California San Diego La Jolla California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4730-0655","authenticated-orcid":false,"given":"Thomas P.","family":"Lodise","sequence":"additional","affiliation":[{"name":"Albany College of Pharmacy and Health Sciences Albany New York United States"},{"name":"Albany Medical Center Hospital Albany New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald P.","family":"Levine","sequence":"additional","affiliation":[{"name":"School of Medicine Wayne State University Detroit Michigan United States"},{"name":"Detroit Receiving Hospital Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John S.","family":"Bradley","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Pediatrics University of California at San Diego La Jolla California"},{"name":"Rady Children\u2019s Hospital San Diego San Diego California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Allergy and Infectious Diseases University of Washington Seattle Washington"},{"name":"Vaccine and Infectious Disease Division Fred Hutchinson Cancer Research Center Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce A.","family":"Mueller","sequence":"additional","affiliation":[{"name":"University of Michigan College of Pharmacy Ann Arbor Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manjunath P.","family":"Pai","sequence":"additional","affiliation":[{"name":"University of Michigan College of Pharmacy Ann Arbor Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie","family":"Wong\u2010Beringer","sequence":"additional","affiliation":[{"name":"University of Southern California School of Pharmacy Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Rotschafer","sequence":"additional","affiliation":[{"name":"University of Minnesota College of Pharmacy Minneapolis Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith A.","family":"Rodvold","sequence":"additional","affiliation":[{"name":"University of Illinois College of Pharmacy Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly D.","family":"Maples","sequence":"additional","affiliation":[{"name":"College of Pharmacy &amp; Arkansas Children\u2019s Hospital University of Arkansas for Medical Sciences Little Rock Arkansas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin M.","family":"Lomaestro","sequence":"additional","affiliation":[{"name":"Albany Medical Center Hospital Albany New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,29]]},"reference":[{"key":"e_1_2_2_2_1","article-title":"Therapeutic monitoring of vancomycin for serious methicillin\u2010resistant Staphylococcus aureus infections: a revised consensus guideline and review of the American Society of Health\u2010System Pharmacists, the Infectious Diseases Society of America, the Pediatric Infectious Diseases Society and the Society of Infectious Diseases Pharmacist","author":"Rybak MJ","journal-title":"Am J Health\u2010Syst"},{"issue":"9","key":"e_1_2_2_3_1","first-page":"1193","article-title":"The periodic health examination. Canadian Task Force on the periodic health examination","volume":"121","year":"1979","journal-title":"Can Med Assoc J"}],"container-title":["Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fphar.2376","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/phar.2376","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/phar.2376","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/phar.2376","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T13:12:14Z","timestamp":1761052334000},"score":1,"resource":{"primary":{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/10.1002\/phar.2376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,29]]},"references-count":2,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1002\/phar.2376"],"URL":"https:\/\/doi.org\/10.1002\/phar.2376","archive":["Portico"],"relation":{},"ISSN":["0277-0008","1875-9114"],"issn-type":[{"value":"0277-0008","type":"print"},{"value":"1875-9114","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,29]]},"assertion":[{"value":"2020-03-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}