{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T23:49:09Z","timestamp":1788824949790,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T00:00:00Z","timestamp":1588809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Surrey Memorial Hospital, Department of Pharmacy"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Torsade de pointes is a form of polymorphic ventricular tachycardia associated with heart rate\u2013corrected QT (QT<jats:sub>c<\/jats:sub>) interval prolongation. With approximately 24\u201361% of critically ill patients experiencing QT<jats:sub>c<\/jats:sub> interval prolongation, a predictive tool to identify high\u2010risk patients could assist in the\u00a0monitoring and management in the intensive care unit (ICU). The Tisdale et al. Risk Score (TRS) is a predictive tool that was developed and validated in a cardiac critical care unit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The objective of this study was to evaluate the predictive validity (sensitivity and specificity) and likelihood ratios of the TRS in a medical ICU.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a longitudinal, retrospective, cohort study of consecutive patients who met the inclusion criteria from October 2017 to June 2018 with a sample size of 264 patients. The sample size was derived based on the number of TRS covariates and an exploratory variable. Baseline characteristics and risk factors were documented from electronic health records. The first occurrence of QT<jats:sub>c<\/jats:sub> interval prolongation, defined as a QT<jats:sub>c<\/jats:sub> interval &gt;\u00a0500\u00a0ms or an increase \u2265\u00a060\u00a0ms above baseline, was the primary endpoint.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Results<\/jats:title><jats:p>The sensitivity and specificity of the TRS for low\u2010risk patients against the moderate\u2010risk and high\u2010risk patients were 97% (95% CI 91\u201399%) and 16% (95% CI 11\u201323%), respectively. These results corresponded to a positive likelihood ratio of 1.15 (95% CI 1.07\u20131.24) and a negative likelihood ratio of 0.20 (95% CI 0.06\u20130.65).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In conclusion, the TRS showed a high sensitivity, making it useful in identifying patients at risk of developing QT<jats:sub>c<\/jats:sub> interval prolongation. Furthermore, patients categorized as low risk by the tool can be considered as having minimal risk of developing QT<jats:sub>c<\/jats:sub> interval prolongation. Given the tool's low specificity, it does not reliably identify all patients at low risk of QT<jats:sub>c<\/jats:sub> interval prolongation.\u00a0<\/jats:p><\/jats:sec>","DOI":"10.1002\/phar.2400","type":"journal-article","created":{"date-parts":[[2020,4,7]],"date-time":"2020-04-07T13:15:45Z","timestamp":1586265345000},"page":"492-499","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Predictive Validity of a QT<sub>c<\/sub> Interval Prolongation Risk Score in the Intensive Care Unit"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9503-7137","authenticated-orcid":false,"given":"Ke","family":"Su","sequence":"first","affiliation":[{"name":"Pharmacy Department Royal Columbian Hospital New Westminster British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rumi","family":"McGloin","sequence":"additional","affiliation":[{"name":"Pharmacy Department Surrey Memorial Hospital Surrey British Columbia Canada"},{"name":"Faculty of Pharmaceutical Sciences University of British Columbia Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rochelle M.","family":"Gellatly","sequence":"additional","affiliation":[{"name":"Pharmacy Department Surrey Memorial Hospital Surrey British Columbia Canada"},{"name":"Faculty of Pharmaceutical Sciences University of British Columbia Vancouver British Columbia Canada"},{"name":"Faculty of Pharmacy and Pharmaceutical Sciences Monash University Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.113.000152"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2007.01.040"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(84)90081-4"},{"key":"e_1_2_6_5_1","first-page":"485","volume-title":"Drug induced diseases. 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