{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:41:42Z","timestamp":1761093702024,"version":"build-2065373602"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T00:00:00Z","timestamp":1600732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec><jats:title>\n<jats:sc>Introduction<\/jats:sc>\n<\/jats:title><jats:p>Vancomycin pharmacokinetic data in critically ill patients receiving sustained low\u2010efficiency dialysis (SLED) is limited. Published data using vancomycin with intermittent hemodialysis and continuous renal replacement therapy may not be applicable to hybrid dialysis modalities such as SLED. Current drug references lack recommendations for vancomycin dosing in patients receiving SLED.<\/jats:p><\/jats:sec><jats:sec><jats:title>\n<jats:sc>Objective<\/jats:sc>\n<\/jats:title><jats:p>The objective of this study was to determine vancomycin pharmacokinetics during SLED.<\/jats:p><\/jats:sec><jats:sec><jats:title>\n<jats:sc>Methods<\/jats:sc>\n<\/jats:title><jats:p>A total of 20 patients who were critically ill with oliguric or anuric renal failure who received vancomycin and SLED were included in the study. Surrounding one SLED session, serum vancomycin blood samples were drawn before the initiation of SLED, at the termination of SLED, and 4\u00a0hours after completion of SLED treatment. Following this, patients received vancomycin, dosed to target a goal peak of 20\u201330\u00a0mcg\/ml. A vancomycin peak level was drawn 1\u00a0hour after the end of the infusion. SLED treatment duration was at least 7\u00a0hours. Continuous data are reported as median (interquartile range) and categorical data as percentage.<\/jats:p><\/jats:sec><jats:sec><jats:title>\n<jats:sc>Results<\/jats:sc>\n<\/jats:title><jats:p>The vancomycin elimination rate and half\u2010life were 0.051\u00a0hours (0.042\u20130.074 hours) and 13.6\u00a0hours (9.4\u201316.6 hours), respectively. SLED reduced vancomycin serum concentrations by 35.4% (31.5\u201343.8%), and vancomycin rebound was 9.8% (2.5\u201313.7%). The vancomycin dose administered post\u2010SLED was 1000\u00a0mg (875\u20131125 mg). For 18 patients, the patient\u2010specific volume of distribution was 0.88\u00a0L\/kg (0.67\u20131.1 L\/kg), vancomycin clearance was 3.5\u00a0L\/hr (2.2\u20135.2 L\/hr), and the area under the concentration\u2010time curve during the study time period was 280.8\u00a0mg\u00b7hr\/L (254.7\u2013297.3 mg\u00b7hr\/L).<\/jats:p><\/jats:sec><jats:sec><jats:title>\n<jats:sc>Conclusion<\/jats:sc>\n<\/jats:title><jats:p>Vancomycin is significantly removed during SLED with little rebound in serum concentrations 4\u00a0hours after completion of SLED. Based on study findings, patients who are critically ill require additional vancomycin dosing after each SLED session to maintain therapeutic post\u2010SLED vancomycin concentrations. Therapeutic drug monitoring of vancomycin is recommended during SLED.<\/jats:p><\/jats:sec>","DOI":"10.1002\/phar.2460","type":"journal-article","created":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T14:51:03Z","timestamp":1598885463000},"page":"1036-1041","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Pharmacokinetics of Vancomycin in Critically Ill Patients Undergoing Sustained Low\u2010Efficiency Dialysis"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1897-1847","authenticated-orcid":false,"given":"Taylor R.","family":"Rider","sequence":"first","affiliation":[{"name":"Department of Pharmacy Rochester General Hospital Rochester New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin M.","family":"Silinskie","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Rochester General Hospital Rochester New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mindee S.","family":"Hite","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Rochester General Hospital Rochester New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Bress","sequence":"additional","affiliation":[{"name":"Nephrology Department Rochester General Hospital Rochester New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,22]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2015.01.013"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000000317"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181aab3d0"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e318206c3b2"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31820e6a0d"},{"issue":"3","key":"e_1_2_5_7_1","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1086\/600390","article-title":"Antibiotic dosing in slow extended daily dialysis","volume":"49","author":"Mushatt DM","year":"2009","journal-title":"Clin Infect Dis"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.060002777.x"},{"issue":"2","key":"e_1_2_5_9_1","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1097\/CCM.0000000000002210","article-title":"Right dose, right now: customized drug dosing in the critically ill","volume":"45","author":"Roberts JA","year":"2017","journal-title":"Crit Care Med"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajhp\/zxaa036"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-139X.2011.00826.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00650112"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/1060028019865873"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/2054358118792229"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-018-0697-6"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7174.2012.00226.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp150051"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2005.07.018"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.5414\/CNP72286"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1592\/phco.29.5.562"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000190243.88133.3F"},{"issue":"1","key":"e_1_2_5_22_1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1159\/000170237","article-title":"Effects of slowly performed daytime hemodialysis (slow HD) on the pharmacokinetics of vancomycin in hemodynamically unstable patients with renal failure","volume":"14","author":"Kihara M","year":"1996","journal-title":"Blood Purif"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2020.02.011"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2018.03.001"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-019-00817-6"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.5507\/bp.2012.002"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/001857870403900208"},{"issue":"3","key":"e_1_2_5_28_1","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1046\/j.1523-1755.2003.00819.x","article-title":"Gentamicin pharmacokinetics during slow daily home hemodialysis","volume":"63","author":"Manley HJ","year":"2003","journal-title":"Kidney Int"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/sdi.12496"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000343162"}],"container-title":["Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/phar.2460","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/phar.2460","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/phar.2460","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T12:10:39Z","timestamp":1761048639000},"score":1,"resource":{"primary":{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/10.1002\/phar.2460"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,22]]},"references-count":29,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1002\/phar.2460"],"URL":"https:\/\/doi.org\/10.1002\/phar.2460","archive":["Portico"],"relation":{},"ISSN":["0277-0008","1875-9114"],"issn-type":[{"type":"print","value":"0277-0008"},{"type":"electronic","value":"1875-9114"}],"subject":[],"published":{"date-parts":[[2020,9,22]]},"assertion":[{"value":"2020-09-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}