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The presence of concomitant disease states is associated with worse outcomes, including increased risk of mortality, decreased quality of life, and increased healthcare resource utilization. Additionally, the presence of heart failure with reduced ejection fraction complicates the management of these comorbidities, including varying safety and efficacy of therapies compared to those without heart failure. This article will review the literature on the pharmacologic management of common noncardiovascular comorbidities\u2014including chronic obstructive pulmonary disease, depression, diabetes mellitus, gout, chronic kidney disease, and iron deficiency\u2014in patients with heart failure with reduced ejection fraction, as well as provide recommendations for appropriate treatment selection in this population.<\/jats:p>","DOI":"10.1002\/phar.2528","type":"journal-article","created":{"date-parts":[[2021,4,20]],"date-time":"2021-04-20T04:53:17Z","timestamp":1618894397000},"page":"537-545","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Management of noncardiovascular comorbidities in patients with heart failure with reduced ejection fraction"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2533-3373","authenticated-orcid":false,"given":"Stormi 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