{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T21:34:35Z","timestamp":1793136875502,"version":"4.5.0"},"reference-count":22,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T00:00:00Z","timestamp":1622073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Effect of pre\u2010transplant amiodarone use on post\u2013heart transplant (HT) survival is not well established. We therefore sought to examine the effect of amiodarone use on post\u2010HT survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We stratified adults who underwent HT between January 2000 and August 2018 in the Scientific Registry of Transplant Recipients according to pre\u2010transplant amiodarone use and used recipient and donor characteristics to calculate propensity scores. We then used overlap propensity score weighting to construct Cox proportional hazards regression models (adjusted for Index for Mortality Prediction After Cardiac Transplantation [IMPACT] score and donor\/recipient predicted heart mass [PHM] ratio) for mortality outcomes. Logistic regression was used to compare the odds of primary graft failure and drug\u2010treated rejection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>25,394 adult HT recipients were included; median (inter\u2010quartile range) age was 55 (46, 62) years and 75.5% were men. Compared with nonusers, amiodarone users had a significantly higher prevalence of hypertension (46.7% vs. 50.2%; <jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.0001), left ventricular assist device (LVAD) use (24.5% vs. 31.3%; <jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.0001), and ventilator support (2.5% vs. 3.6%; <jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.0001), respectively. The 10\u2010year post\u2010HT mortality rate in the overall population was 32.0%. Amiodarone use was associated with higher post\u2010transplant 30\u2010day (hazard ratio (HR) 1.25, 95% confidence interval (CI) 1.11\u20131.41) and 1\u2010year mortality (HR 1.13, 1.04\u20131.22), but similar 5\u2010year (HR 1.01, 95% CI 0.96\u20131.07) and 10\u2010year mortality (HR 1.05, 95% CI 0.98\u20131.13). Amiodarone use increased primary graft failure risk (odds ratio (OR) 1.30, 95% CI 1.07\u20131.57) but decreased drug\u2010treated rejection (OR 0.81, 95% CI 0.70\u20130.93).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although pre\u2010transplant amiodarone was associated with higher short\u2010term mortality, its use did not affect long\u2010term survival. Whether the short\u2010term outcomes are related to greater graft failure risk is unclear.<\/jats:p><\/jats:sec>","DOI":"10.1002\/phar.2533","type":"journal-article","created":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T17:52:32Z","timestamp":1620323552000},"page":"1024-1032","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Pre\u2010transplant amiodarone use does not affect long\u2010term heart transplant survival"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5554-2104","authenticated-orcid":false,"given":"Douglas L.","family":"Jennings","sequence":"first","affiliation":[{"name":"Department of Pharmacy Practice Long Island University New York NY USA"},{"name":"New York\u2010Presbyterian Hospital Columbia University Irving Medical Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naga","family":"Vaishnavi Gadela","sequence":"additional","affiliation":[{"name":"Hartford HealthCare Heart and Vascular Institute Hartford Hospital Hartford CT USA"},{"name":"Department of Internal Medicine University of Connecticut Farmington CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek","family":"Jaiswal","sequence":"additional","affiliation":[{"name":"Hartford HealthCare Heart and Vascular Institute Hartford Hospital Hartford CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Touch","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice University of Connecticut School of Pharmacy Storrs CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2172-0931","authenticated-orcid":false,"given":"William L.","family":"Baker","sequence":"additional","affiliation":[{"name":"Hartford HealthCare Heart and Vascular Institute Hartford Hospital Hartford CT USA"},{"name":"Department of Pharmacy Practice University of Connecticut School of Pharmacy Storrs CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,27]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"Adult heart allocation \u2010 OPTN.https:\/\/optn.transplant.hrsa.gov\/learn\/professional\u2010education\/adult\u2010heart\u2010allocation\/. 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