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However, developing successful pharmacotherapy regimens based on those pathways has proven more of a challenge. This narrative review provides an overview of five common arrhythmias impacted by inflammation, including atrial fibrillation (AF), myocardial infarction, arrhythmogenic cardiomyopathy, cardiac sarcoidosis, and QT prolongation, and the potential role for anti\u2010inflammatory therapy in their management. We identified arrhythmias and arrhythmogenic disease states with the most evidence linking pathogenesis to inflammation and conducted comprehensive searches of United States National Library of Medicine MEDLINE<jats:sup>\u00ae<\/jats:sup> and PubMed databases. Although a variety of agents have been studied for the management of AF, primarily in an effort to reduce postoperative AF following cardiac surgery, no standard anti\u2010inflammatory agents are used in clinical practice at this time. Although inflammation following myocardial infarction may contribute to the development of VA, there is no clear benefit with the use of anti\u2010inflammatory agents at this time. Similarly, although inflammation is clearly linked to the development of arrhythmias in arrhythmogenic cardiomyopathy, data demonstrating a benefit with anti\u2010inflammatory agents are limited. Cardiac sarcoidosis, an infiltrative disease eliciting an immune response, is primarily treated by immunosuppressive therapy and steroids, despite a lack of primary literature to support such regimens. In this case, anti\u2010inflammatory agents are frequently used in clinical practice. The pathophysiology of arrhythmias is complex, and inflammation likely plays a role in both onset and duration, however, for most arrhythmias the role of pharmacotherapy targeting inflammation remains unclear.<\/jats:p>","DOI":"10.1002\/phar.2663","type":"journal-article","created":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T03:51:08Z","timestamp":1643601068000},"page":"250-262","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["The role of inflammation in the pathogenesis and treatment of arrhythmias"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1516-4118","authenticated-orcid":false,"given":"Anastasia L.","family":"Armbruster","sequence":"first","affiliation":[{"name":"St. Louis College of Pharmacy University of Health Sciences and Pharmacy in St. Louis  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen Bova","family":"Campbell","sequence":"additional","affiliation":[{"name":"Duke University Hospital  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milan G.","family":"Kahanda","sequence":"additional","affiliation":[{"name":"Cardiovascular Division Department of Internal Medicine Washington University in St. Louis School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip S.","family":"Cuculich","sequence":"additional","affiliation":[{"name":"Cardiovascular Division Department of Internal Medicine Washington University in St. Louis School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,14]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa612"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2004.01.026"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.10.3542"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr285"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/joa3.12077"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv486"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2015.2"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.06.1313"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2013.08.078"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2006.09.015"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi645"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-015-0068-3"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.07.031"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.026153"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.04.057"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.03.022"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.11.070"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.04.079"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.12.029"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.621763"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d1250"},{"key":"e_1_2_5_23_1","first-page":"100573","article-title":"Assessment of OMT\u201028, a synthetic analog of omega\u20103 epoxyeicosanoids, in patients with persistent atrial fibrillation: rationale and design of the PROMISE\u2010AF phase II study","volume":"29","author":"Berlin S","year":"2020","journal-title":"Int J Cardiol Heart Vasc"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.119.008197"},{"key":"e_1_2_5_25_1","unstructured":"World Health Organization[Internet] \u201cThe Top 10 Causes of Death.\u201dWorld Health Organization World Health Organization.www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/the\u2010top\u201010\u2010causes\u2010of\u2010death. 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