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There was a statistically significant reduction in median NPRS by 1.5 (1\u20134), 3 (2\u20133), and 4 (3\u20135) points at 60 min after receiving the medication and remained decreased by 1.5 (1\u20132), 2 (1\u20132) and 1 (1\u20134) points at the end of the study visit (240 min) with the 10 mg, 30 mg and 50 mg IN dosage, respectively. The median percentage of maximal pain relief being 22.5 (16.6\u201371.5), 65.5 (40\u2013100), and 69.25 (50\u2013100) for 10 mg, 30 mg and 50 mg IN dosage, respectively and 100 (75\u2013100) with 10 mg IV dose. All side effects (nausea and feeling of unreality) resolved by the end of each study visit. No severe adverse events occurred.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this single\u2010institution study, all dosages of IN ketamine administered in the study (10, 30, and 50 mg) provided significant pain relief for intractable cancer\u2010related pain and were well tolerated. The 50 mg dose provided maximal pain relief without major side effects. Further study focused on repeated administration efficacy and safety for cancer\u2010related pain is warranted.<\/jats:p><\/jats:sec>","DOI":"10.1002\/phar.2669","type":"journal-article","created":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T03:31:36Z","timestamp":1644550296000},"page":"298-310","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["A dose\u2010escalation clinical trial of intranasal ketamine for uncontrolled cancer\u2010related pain"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8103-1401","authenticated-orcid":false,"given":"Vinita","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa W.","family":"Gillespie","sequence":"additional","affiliation":[{"name":"Department of Hematology and Medical Oncology Emory University School of Medicine  Atlanta Georgia USA"},{"name":"Department of Surgery Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olabisi","family":"Lane","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Spektor","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali John","family":"Zarrabi","sequence":"additional","affiliation":[{"name":"Department of Family Medicine Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Egan","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly","family":"Curseen","sequence":"additional","affiliation":[{"name":"Department of Family Medicine Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya","family":"Tsvetkova","sequence":"additional","affiliation":[{"name":"Cancer Therapeutics Program UPMC Hillman Cancer Center  Pittsburgh Pennsylvania USA"},{"name":"Department of Pharmaceutical Sciences School of Pharmacy University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan H.","family":"Beumer","sequence":"additional","affiliation":[{"name":"Cancer Therapeutics Program UPMC Hillman Cancer Center  Pittsburgh Pennsylvania USA"},{"name":"Department of Pharmaceutical Sciences School of Pharmacy University of Pittsburgh  Pittsburgh Pennsylvania USA"},{"name":"Division of Hematology\u2010Oncology Department of Medicine University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Sniecinski","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack\u00a0W.","family":"Shteamer","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffery","family":"Switchenko","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Bioinformatics Rollins School of Public Health Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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