{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:51:55Z","timestamp":1786978315239,"version":"build-2736575974"},"reference-count":43,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,6,4]],"date-time":"2022-06-04T00:00:00Z","timestamp":1654300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Cefiderocol is a siderophore cephalosporin recently approved by the United States Food and Drug Administration for the treatment of hospital\u2010 and ventilator\u2010acquired bacterial pneumonia and complicated urinary tract infections. However, there is potential for cefiderocol utility for a variety of other infections. The purpose of this systematic review was to identify literature examining the safety and efficacy of cefiderocol for off\u2010label indications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The PRISMA guidelines were utilized for reporting. Databases searched included PubMed, Scopus, and Embase, from inception to September 2021. Manuscripts describing cefiderocol off\u2010label use in clinical settings were included. Exclusion criteria were studies focused on labeled indications, animal studies, pharmacodynamic\/pharmacokinetic studies, in vitro or laboratory studies, and manuscripts in languages other than English or Arabic. Each stage of review utilized two independent investigators, with conflicts resolved and critical appraisal performed. Data regarding presentation, clinical course, and infection characteristics were extracted and descriptively analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The search identified a total of 985 records, narrowed to a final set of 27 studies. Among studies included were 18 (66.7%) case reports, 8 (29.6%) case series, and 1 (3.7%) phase 3 clinical trial. Cefiderocol was most frequently used off\u2010label for bacteremia\/sepsis with or without an identified source in 51 (67.1%) out of a total of 76 included patients. Among case series\/reports with available data, 43 of 53 patients (81.1%) received combination antibiotic therapy. The most common pathogens identified included multi\/extensively drug\u2010resistant\n                      <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                      and\/or\n                      <jats:italic>Acinetobacter baumannii<\/jats:italic>\n                      . Various clinical end points were reported, while microbiological end points were reported in 18 (66.7%) studies. Cefiderocol\u2010related side effects were uncommon and rarely use\u2010limiting.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This systematic review depicts relative clinical effectiveness of off\u2010label cefiderocol, most commonly for\n                      <jats:italic>P. aeruginosa<\/jats:italic>\n                      and\n                      <jats:italic>A. baumannii<\/jats:italic>\n                      infections as combination antibiotic therapy. Further study is needed to elucidate the safety and efficacy of cefiderocol across an expanded set of patients and indications.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/phar.2704","type":"journal-article","created":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T03:55:27Z","timestamp":1653450927000},"page":"549-566","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Safety and efficacy of cefiderocol for off\u2010label treatment indications: A systematic review"],"prefix":"10.1002","volume":"42","author":[{"given":"Riyan","family":"Babidhan","sequence":"first","affiliation":[{"name":"Duquesne University School of Pharmacy  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigale","family":"Lewis","sequence":"additional","affiliation":[{"name":"Duquesne University School of Pharmacy  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cailin","family":"Atkins","sequence":"additional","affiliation":[{"name":"Duquesne University School of Pharmacy  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas J.","family":"Jozefczyk","sequence":"additional","affiliation":[{"name":"Duquesne University School of Pharmacy  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Branden\u00a0D.","family":"Nemecek","sequence":"additional","affiliation":[{"name":"Duquesne University School of Pharmacy  Pittsburgh Pennsylvania USA"},{"name":"University of Pittsburgh Medical Center \u2013 Mercy Hospital  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9839-2510","authenticated-orcid":false,"given":"Courtney A.","family":"Montepara","sequence":"additional","affiliation":[{"name":"Duquesne University School of Pharmacy  Pittsburgh Pennsylvania USA"},{"name":"Allegheny General Hospital  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1391-7072","authenticated-orcid":false,"given":"Michael R.","family":"Gionfriddo","sequence":"additional","affiliation":[{"name":"Duquesne University School of Pharmacy  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David\u00a0E.","family":"Zimmerman","sequence":"additional","affiliation":[{"name":"Duquesne University School of Pharmacy  Pittsburgh Pennsylvania USA"},{"name":"University of Pittsburgh Medical Center \u2013 Mercy Hospital  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2913-2042","authenticated-orcid":false,"given":"Jordan R.","family":"Covvey","sequence":"additional","affiliation":[{"name":"Duquesne University School of Pharmacy  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9019-8847","authenticated-orcid":false,"given":"Anthony J.","family":"Guarascio","sequence":"additional","affiliation":[{"name":"Duquesne University School of Pharmacy  Pittsburgh Pennsylvania USA"},{"name":"Allegheny General Hospital  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,4]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"Centers for Disease Control and Prevention.Antibiotic\/antimicrobial resistance (AR\/AMR). 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