{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:54:11Z","timestamp":1786978451333,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T00:00:00Z","timestamp":1668988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Study Objective<\/jats:title>\n                    <jats:p>\n                      The preferred antibiotic salvage regimen for persistent methicillin\u2010resistant\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                      bacteremia (MRSAB) is unclear. We sought to evaluate the effectiveness and safety of vancomycin plus ceftaroline for persistent MRSAB. The primary outcome was time to MRSAB clearance post\u2010ceftaroline initiation. Secondary outcomes included microbiological cure, hospital length of stay, 90\u2010day readmission for MRSAB, 90\u2010day all\u2010cause mortality, MRSAB\u2010related mortality, and incidence of antibiotic\u2010associated adverse effects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Single\u2010center, retrospective cohort study between January 1, 2016, and December 31, 2021.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>State University of New York Upstate University Hospital, a 748\u2010bed tertiary care, academic medical center in Syracuse, NY.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients<\/jats:title>\n                    <jats:p>Adult patients were included if they had blood cultures positive for MRSA \u226572\u2009h, received vancomycin monotherapy initially, and received vancomycin plus ceftaroline for \u226524\u2009h. Patients were excluded if they received other anti\u2010MRSA antibiotics, were pregnant, or were incarcerated. Of the 178 patients identified, 30 unique patients were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>\n                      Patients were medically complex with a median Pitt bacteremia score of 3, 63.3% (19\/30) were admitted to the intensive care unit, and 66.7% (20\/30) had infective endocarditis. Vancomycin\u2010associated acute kidney injury was observed in 10% (3\/30) of patients, which resulted in dose adjustments. No patients experienced ceftaroline\u2010associated neutropenia or\n                      <jats:italic>Clostridioides difficile<\/jats:italic>\n                      infection, but 6.7% (2\/30) developed a rash attributed to ceftaroline. Median time to MRSAB clearance post\u2010ceftaroline initiation was 2.6\u2009days. Microbiologic cure occurred in nearly all patients 96.7% (29\/30). Median hospital length of stay was 19.5\u2009days, and 6.7% (2\/30) of patients had 90\u2010day readmission for MRSAB. 90\u2010day all\u2010cause mortality and MRSAB\u2010related mortality occurred in 26.7% (8\/30) and 13.3% (4\/30) of patients, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Vancomycin plus ceftaroline may represent an effective and well\u2010tolerated salvage regimen option for persistent MRSAB.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/phar.2741","type":"journal-article","created":{"date-parts":[[2022,11,13]],"date-time":"2022-11-13T02:21:49Z","timestamp":1668306109000},"page":"15-23","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Vancomycin plus ceftaroline for persistent methicillin\u2010resistant\n                    <i>Staphylococcus aureus<\/i>\n                    bacteremia"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7703-096X","authenticated-orcid":false,"given":"Wesley D.","family":"Kufel","sequence":"first","affiliation":[{"name":"Binghamton University School of Pharmacy and Pharmaceutical Sciences  Binghamton New York USA"},{"name":"State University of New York Upstate Medical University  Syracuse New York USA"},{"name":"State University of New York Upstate University Hospital  Syracuse New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6082-0137","authenticated-orcid":false,"given":"Katie A.","family":"Parsels","sequence":"additional","affiliation":[{"name":"State University of New York Upstate Medical University  Syracuse New York USA"},{"name":"State University of New York Upstate University Hospital  Syracuse New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce E.","family":"Blaine","sequence":"additional","affiliation":[{"name":"Saint John Fisher University  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey M.","family":"Steele","sequence":"additional","affiliation":[{"name":"State University of New York Upstate Medical University  Syracuse New York USA"},{"name":"State University of New York Upstate University Hospital  Syracuse New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Mahapatra","sequence":"additional","affiliation":[{"name":"State University of New York Upstate Medical University  Syracuse New York USA"},{"name":"State University of New York Upstate University Hospital  Syracuse New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristopher M.","family":"Paolino","sequence":"additional","affiliation":[{"name":"State University of New York Upstate Medical University  Syracuse New York USA"},{"name":"State University of New York Upstate University Hospital  Syracuse New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Thomas","sequence":"additional","affiliation":[{"name":"State University of New York Upstate Medical University  Syracuse New York USA"},{"name":"State University of New York Upstate University Hospital  Syracuse New York 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