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Historically, antistaphylococcal penicillins such as nafcillin were recommended for the treatment of methicillin\u2010susceptible staphylococcal CNS infections. However, the use of antistaphylococcal penicillins presents challenges, such as frequent dosing administration and adverse events with protracted use. This narrative reviews available clinical and pharmacokinetic\/pharmacodynamic (PK\/PD) data for cefazolin in CNS infections and produces a recommendation for use. Based on the limited available evidence analyzed, dose optimized cefazolin is likely a safe and effective alternative to antistaphylococcal penicillins for a variety of CNS infections due to methicillin\u2010susceptible\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    . Given the site of infection and wide therapeutic index of cefazolin, practitioners may consider dosing cefazolin regimens of 2\u00a0g IV every 6\u2009h or a continuous infusion of 8\u201310\u00a0g daily instead of 2\u00a0g IV every 8\u2009h to optimize PK\/PD properties.\n                  <\/jats:p>","DOI":"10.1002\/phar.2750","type":"journal-article","created":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T20:29:21Z","timestamp":1671136161000},"page":"85-95","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Cefazolin in the treatment of central nervous system infections: A narrative review and recommendation"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0340-3409","authenticated-orcid":false,"given":"Kayla","family":"Antosz","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy and Outcomes Sciences University of South Carolina College of Pharmacy  Columbia South Carolina USA"},{"name":"Prisma Health\u2010Midlands  Columbia South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Battle","sequence":"additional","affiliation":[{"name":"Prisma Health\u2010Midlands  Columbia South Carolina USA"},{"name":"Department of Medicine, Division of Infectious Diseases University of South Carolina School of Medicine  Columbia South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Chang","sequence":"additional","affiliation":[{"name":"Pharmacometrics Center of Excellence, Department of Pharmacy Practice Midwestern University College of Pharmacy  Downers Grove Illinois USA"},{"name":"Department of Pharmacy Northwestern Memorial Hospital  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1091-6130","authenticated-orcid":false,"given":"Marc H.","family":"Scheetz","sequence":"additional","affiliation":[{"name":"Pharmacometrics Center of Excellence, Department of Pharmacy Practice Midwestern University College of Pharmacy  Downers Grove Illinois USA"},{"name":"Department of Pharmacy Northwestern Memorial Hospital  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6501-492X","authenticated-orcid":false,"given":"Majdi","family":"Al\u2010Hasan","sequence":"additional","affiliation":[{"name":"Prisma Health\u2010Midlands  Columbia South Carolina USA"},{"name":"Department of Medicine, Division of Infectious Diseases University of South Carolina School of Medicine  Columbia South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4409-0963","authenticated-orcid":false,"given":"P. 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