{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T20:52:55Z","timestamp":1789764775835,"version":"4.0.1"},"reference-count":67,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T00:00:00Z","timestamp":1678924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Liposomal amphotericin B (LAmB) is used in the treatment of opportunistic fungal and parasitic infections, including leishmaniasis. Given its lack of known teratogenicity in pregnancy, LAmB is a preferred agent for treatment for these patients. However, significant gaps remain in determining optimal dosing regimens for LAmB in pregnancy. We describe the use of LAmB for a pregnant patient with mucocutaneous leishmaniasis (MCL) using a dosing strategy of 5\u00a0mg\/kg\/day for days\u20091\u20137 using ideal body weight followed by 4\u00a0mg\/kg weekly using adjusted body weight. We reviewed the literature for LAmB dosing strategies, particularly dosing weight, in pregnancy. Of the 143 cases identified in 17 studies, only one reported a dosing weight, in which ideal body weight was used. Five Infectious Diseases Society of America guidelines in total discussed the use of amphotericin B in pregnancy but no guidelines included recommendations for dosing weight. This review describes our experience in using ideal body weight for dosing LAmB in pregnancy for the treatment of MCL. Use of ideal body weight may minimize risk of adverse effects to the fetus compared to the use of total body weight while maintaining efficacy for treatment of MCL in pregnancy.<\/jats:p>","DOI":"10.1002\/phar.2784","type":"journal-article","created":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T09:23:47Z","timestamp":1677749027000},"page":"452-462","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Dosing implications for liposomal amphotericin B in pregnancy"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8050-0408","authenticated-orcid":false,"given":"Niamh","family":"O'Grady","sequence":"first","affiliation":[{"name":"Department of Pharmacy Yale\u2010New Haven Hospital  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8153-3284","authenticated-orcid":false,"given":"Dayna","family":"McManus","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Yale\u2010New Haven Hospital  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5583-7057","authenticated-orcid":false,"given":"Neima","family":"Briggs","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Infectious Disease Section Yale\u2010New Haven Hospital  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5498-5042","authenticated-orcid":false,"given":"Marwan M.","family":"Azar","sequence":"additional","affiliation":[{"name":"Department of Section of Infectious Diseases, Department of Internal Medicine Yale School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4308-2352","authenticated-orcid":false,"given":"Jeffrey","family":"Topal","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Infectious Disease Section Yale\u2010New Haven Hospital  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6509-0487","authenticated-orcid":false,"given":"Matthew W.","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Yale\u2010New Haven Hospital  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1994.50.296"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2010.06.013"},{"key":"e_1_2_10_4_1","unstructured":"Prevention CC for DC and CDC \u2010 Leishmaniasis \u2010 Resources for Health Professionals. July 5 2022. Accessed July 20 2022.https:\/\/www.cdc.gov\/parasites\/leishmaniasis\/health_professionals\/index.html"},{"key":"e_1_2_10_5_1","unstructured":"World Health Organization.Leishmaniasis. Weekly epidemiological record No 22. 2016. Accessed July 20 2022.https:\/\/www.who.int\/health\u2010topics\/leishmaniasis"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/805108"},{"key":"e_1_2_10_7_1","unstructured":"World Health Organization.Leishmaniasis. January 8 2022. Accessed July 20 2022.https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/leishmaniasis"},{"key":"e_1_2_10_8_1","unstructured":"European Centre for Disease Prevention and Control.Facts about leishmaniasis. Accessed August 13 2022.https:\/\/www.ecdc.europa.eu\/en\/leishmaniasis\/facts"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2011.10-0556"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20143073"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1211.060152"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/378472"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.1995.tb00907.x"},{"issue":"2","key":"e_1_2_10_14_1","first-page":"353","article-title":"Cellular immunity in pregnancy: subpopulations of T lymphocytes bearing fc receptors for IgG and IgM in pregnant women","volume":"41","author":"Hirahara F","year":"1980","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.164.4.454"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1086\/520017"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.12-0716"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1590\/0037-8682-0233-2018"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2017.08.012"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ram.2020.08.003"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0009650"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw742"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD010481.pub2"},{"key":"e_1_2_10_24_1","unstructured":"Food and Drug Administration.IMPAVIDO (miltefosine) capsules for oral use Package Insert. Accessed July 19 2022.https:\/\/www.impavido.com\/_files\/ugd\/a54292_eb861bfce29a43a185892ee0a7b15edb.pdf"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2009.08.002"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0890-6238(01)00127-7"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-013-0069-4"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.2147\/nano.2006.1.4.417"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/49.suppl_1.81"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofac360"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-016-0538-7"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2015.08.002"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/22.6.938"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.riam.2009.06.003"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0007992"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/tmi.12238"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl342"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-007-0532-0"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkh538"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2010.10-0156"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkg340"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpids\/piz055"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijwd.2018.11.002"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpt.12609"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2017.02.015"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005134"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.5935\/0101-2800.20150041"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir674"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1179\/146532810X12703902516400"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0163-4453(03)00002-1"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1086\/588300"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ933"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw360"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1086\/521259"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2012.00099"},{"key":"e_1_2_10_56_1","unstructured":"Food and Drug Administration.Ambisome (amphotericin B) liposome for injection Package Insert. July 2020.https:\/\/www.astellas.us\/docs\/ambisome.pdf"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.3.834-840.2002"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0903627"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02366-20"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-72386-0"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13356-2"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1199326"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1963.tb04922.x"},{"key":"e_1_2_10_64_1","volume-title":"Maternal, Fetal & Neonatal Physiology: A Clinical Perspective","author":"Blackburn S","year":"2016"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz076"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1164\/arrd.1982.126.2.350"},{"issue":"5","key":"e_1_2_10_67_1","first-page":"485","article-title":"Disseminated blastomycosis in a pregnant woman successfully treated with amphotericin\u2010B. a case report","volume":"33","author":"Hager H","year":"1988","journal-title":"J Reprod Med"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1980.124"}],"container-title":["Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/phar.2784","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/phar.2784","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/phar.2784","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:15:55Z","timestamp":1761059755000},"score":1,"resource":{"primary":{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/10.1002\/phar.2784"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,16]]},"references-count":67,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1002\/phar.2784"],"URL":"https:\/\/doi.org\/10.1002\/phar.2784","archive":["Portico"],"relation":{},"ISSN":["0277-0008","1875-9114"],"issn-type":[{"value":"0277-0008","type":"print"},{"value":"1875-9114","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,16]]},"assertion":[{"value":"2022-10-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}