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Mineralocorticoid receptor antagonists (MRA) are an important component of guideline\u2010directed medical therapy for heart failure to improve clinical outcomes. Clinical trial evidence in heart failure with reduced ejection fraction (HFrEF) informed a strong guideline recommendation for use of MRA in symptomatic patients, barring contraindications. In heart failure with mildly reduced ejection fraction (HFmrEF) and in heart failure with preserved ejection fraction (HFpEF), data are less robust, and this drug class received a weaker recommendation in the heart failure treatment guidelines. Thus, careful selection of patients with HFmrEF\/HFpEF who are most likely to benefit from MRA is paramount to better optimize use of these medications. The purpose of this narrative review is to outline the rationale for the use of MRA in heart failure, summarize the clinical trial evidence for MRA in HFmrEF\/HFpEF, discuss clinical considerations for their use, and describe investigations of nonsteroidal MRA in HFmrEF\/HFpEF.<\/jats:p>","DOI":"10.1002\/phar.2801","type":"journal-article","created":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T07:48:55Z","timestamp":1680767335000},"page":"563-569","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Patient selection for mineralocorticoid receptor antagonists in heart failure with mildly reduced or preserved ejection fraction"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6387-1351","authenticated-orcid":false,"given":"Orly","family":"Vardeny","sequence":"first","affiliation":[{"name":"Center for Care Delivery and Outcomes Research Minneapolis VA Health Care System  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