{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:48:41Z","timestamp":1761058121353,"version":"build-2065373602"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T00:00:00Z","timestamp":1682467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Study Objective<\/jats:title><jats:p>This report highlights the effects of discontinuing venlafaxine on thyroid function in an older adult with previously well\u2010managed Hashimoto thyroiditis and sleep apnea.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Concurrent intervention. Case study. Setting Community\u2010based psychiatry practice Patient \u2010 66 year old female Intervention Over 8\u2009months, a 66\u2010year\u2010old patient slowly reduced the venlafaxine dose. She was treated simultaneously for sleep apnea. Measurements Clinical data including venlafaxine and levothyroxine dosing, thyroid hormone laboratory values, subjective complaints, and objective electrocardiographic (ECG) findings were aggregated and analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Results<\/jats:title><jats:p>As venlafaxine dose was decreased over time, the patient complained of bounding heart palpitations shown to be premature ventricular contractions, and wide and narrow complex ventricular tachycardia on ECG. Thyroid\u2010stimulating hormone decreased from a baseline value of 0.791\u2009uIU\/mL to a nadir of 0.18\u2009uIU\/mL during venlafaxine dosage reduction from 225\u2009mg\/day to 155\u2009mg\/day. Cardiac symptoms subsided following levothyroxine dosage reduction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There was a direct relationship between antidepressant dosage reduction and levothyroxine dosage requirements. Cautious monitoring is recommended during venlafaxine deprescribing in patients with pre\u2010existing thyroid disease.<\/jats:p><\/jats:sec>","DOI":"10.1002\/phar.2803","type":"journal-article","created":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T08:51:50Z","timestamp":1681375910000},"page":"570-573","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Venlafaxine deprescribing and thyroid function"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3979-1706","authenticated-orcid":false,"given":"Barbara J.","family":"Zarowitz","sequence":"first","affiliation":[{"name":"Peter Lamy Center on Drug Therapy and Aging University of Maryland School of Pharmacy  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaily","family":"Jain","sequence":"additional","affiliation":[{"name":"Cairn Center  Las Vegas Nevada USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,4,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjopharm.2007.10.001"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.2003.02007.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2015.0324"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2019.08.031"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-75888-8"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2020.06.012"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/2042098618791371"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2018.09.018"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200124030-00003"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.4088\/PCC.18m02311"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2007.12.029"},{"key":"e_1_2_9_13_1","unstructured":"EdwardsM.Mandibular advancement device SleepApnea.org.https:\/\/www.sleepapnea.org\/treatment\/sleep\u2010apnea\u2010mouth\u2010guard\/. 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