{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:05:38Z","timestamp":1792188338835,"version":"4.4.0"},"reference-count":15,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T00:00:00Z","timestamp":1686182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The presence of extracorporeal membrane oxygenation (ECMO) in addition to underlying critical illness can affect the pharmacokinetics and pharmacodynamics of drugs that are often required to treat this patient population. While ampicillin is the preferred agent for the treatment of susceptible <jats:italic>Enterococcus faecalis<\/jats:italic> infections, there are no in vivo pharmacokinetic studies regarding ampicillin dosing in patients receiving ECMO. This case report consists of two patients on venovenous ECMO with <jats:italic>E. faecalis<\/jats:italic> bloodstream infections in which ampicillin serum concentrations were measured. Pharmacokinetic parameters were calculated using a one compartment open model. Ampicillin trough levels were 5.87 and 39.2\u2009mg\/L for patients A and B, respectively. Based on these results, ampicillin concentrations were found to be above the minimum inhibitory concentration (MIC) for 100% of the dosing interval. The findings of this case report demonstrate that therapeutic concentrations of ampicillin can be obtained in patients on ECMO and therapeutic drug monitoring can be utilized to ensure adequate serum concentrations are achieved.<\/jats:p>","DOI":"10.1002\/phar.2832","type":"journal-article","created":{"date-parts":[[2023,5,27]],"date-time":"2023-05-27T05:18:14Z","timestamp":1685164694000},"page":"864-868","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Pharmacokinetics of ampicillin during venovenous extracorporeal membrane oxygenation: A case report"],"prefix":"10.1002","volume":"43","author":[{"given":"Sarah","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Pharmacy Providence Portland Medical Center  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas L.","family":"Stucky","sequence":"additional","affiliation":[{"name":"Department of Medicine Section of Infectious Diseases, Providence Portland Medical Center  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendi","family":"Drummond","sequence":"additional","affiliation":[{"name":"Department of Medicine Section of Infectious Diseases, Providence Portland Medical Center  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fawzy","family":"Elbarbry","sequence":"additional","affiliation":[{"name":"School of Pharmacy Pacific University  Hillsboro Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8585-1722","authenticated-orcid":false,"given":"Brent W.","family":"Footer","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Providence Portland Medical Center  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,8]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/phar.1882"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-017-1644-y"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.accpm.2019.02.015"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc9091"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu027"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000296"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2017.09.154"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-007-0606-2"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1310\/hpj4409-751"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12232"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.33.9.1470"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/24.4.573"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1086\/516284"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dky314"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40560-020-00504-w"}],"container-title":["Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/phar.2832","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T12:33:37Z","timestamp":1761050017000},"score":1,"resource":{"primary":{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/10.1002\/phar.2832"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,8]]},"references-count":15,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1002\/phar.2832"],"URL":"https:\/\/doi.org\/10.1002\/phar.2832","archive":["Portico"],"relation":{},"ISSN":["0277-0008","1875-9114"],"issn-type":[{"value":"0277-0008","type":"print"},{"value":"1875-9114","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,8]]},"assertion":[{"value":"2023-01-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}