{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:10:38Z","timestamp":1791835838395,"version":"4.3.4"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T00:00:00Z","timestamp":1692576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This systematic review and meta\u2010analysis aimed to assess the efficacy and safety of risdiplam on motor and respiratory function in spinal muscular atrophy (SMA). We systematically searched Medline, Scopus, Web of Science, and the Cochrane Library from inception to March 2023. We included pre\u2010post studies that determined the effect of risdiplam on the Children's Hospital of Philadelphia Infant Test of Neuromuscular Disorders (CHOP\u2010INTEND), the 32\u2010item Motor Function Measure (MFM32), the Revised Upper Limb Module (RULM), the Hammersmith Functional Motor Scale \u2013 Expanded (HFMSE), respiratory function, and the proportion of risdiplam\u2010related adverse events in a population with SMA (phenotypes 1 and 2\/3). Meta\u2010analyses were also performed where possible. Eleven studies were included. After 12\u2009months of treatment, 57% of participants with SMA1 achieved a CHOP\u2010INTEND score\u2009\u2265\u200940 points, and more than half were able to feed orally and had head control. In SMA2\/3, MFM32, RULM, and HFMSE increased by 2.09 (1.17, 3.01), 1.73 (1.25, 2.20), and 1.00 (0.40, 1.59) points, respectively. Efficacy on respiratory function in SMA2\/3 was inconsistent. Finally, 16% of participants experienced adverse events, but serious adverse events could not be quantified due to a lack of cases. The limited available evidence suggests that risdiplam is an effective and safe drug for the treatment of SMA. In addition, long\u2010term clinical benefit may be partly determined by the stage of disease at which treatment is initiated.<\/jats:p>","DOI":"10.1002\/phar.2866","type":"journal-article","created":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T01:14:19Z","timestamp":1691975659000},"page":"97-105","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Efficacy of risdiplam in spinal muscular atrophy: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1154-8752","authenticated-orcid":false,"given":"Carlos","family":"Pascual\u2010Morena","sequence":"first","affiliation":[{"name":"Health and Social Research Center Universidad de Castilla \u2013 La Mancha  Cuenca 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