{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:41:02Z","timestamp":1790185262461,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T00:00:00Z","timestamp":1702339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>\n                      Acid\u2010suppressive drugs (ASDs) are widely used in many gastric acid\u2010associated diseases. Nocturnal acid breakthrough has been a common problem of many ASDs, such as proton\u2010pump inhibitors (PPIs) and H\n                      <jats:sub>2<\/jats:sub>\n                      \u2010receptor antagonists (H2RAs). Potassium\u2010competitive acid blockers (P\u2010CABs) are expected to solve this continuing conundrum. This article examined major ASDs and compared them with placebo in terms of nocturnal acid\u2010inhibitory effects, using a network meta\u2010analysis of randomized controlled trials (RCTs).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>To compare the effectiveness of major ASDs, a Bayesian network meta\u2010analysis (NMA) was applied to process data extracted from RCTs. The plausible ranking for each regimen and some subgroups were assessed by surface under the cumulative ranking curves (SUCRA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fifty\u2010five RCTs were conducted with 2015 participants. In terms of nocturnal acid\u2010inhibitory effects, the overall results showed that tegoprazan (SUCRA 91.8%) and vonoprazan (SUCRA 91.0%) had the best performance, followed by new PPIs (including tenatoprazole and ilaprazole) (SUCRA 76.6%), additional H2RAs once at bedtime (AHB) (SUCRA 61.3%), isomer PPIs (including esomeprazole and dexlansoprazole) (SUCRA 38.6%), revaprazan (SUCRA 34.7%), traditional PPIs (including omeprazole, rabeprazole, pantoprazole, lansoprazole) (SUCRA 32.6%), H2RAs (SUCRA 23.1%), and placebo (SUCRA 0.3%). In some subgroups, the nocturnal acid\u2010inhibitory effect of vonoprazan or tegoprazan was better than most of the other regimens, even new PPIs and AHB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This is the first study to compare the effect of ASDs on inhibiting nocturnal acid breakthrough. Overall, in terms of nocturnal acid\u2010inhibitory effect, vonoprazan and tegoprazan had an advantage against other regimens including H2RAs, isomer PPIs, traditional PPIs, AHB, and new PPIs. Even in some subgroups, such as language classification (English), types of study design (crossover\u2010RCT), age (\u226440\u2009years), BMI (18.5\u201324.9\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ), continent (Asia and North America), disease status (health), the duration of therapy (2\u2009weeks), and time of administration (at daytime or at night\u2010time), the nocturnal acid\u2010inhibitory effect of vonoprazan or tegoprazan were better than most regimens, even AHB and new PPIs.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/phar.2899","type":"journal-article","created":{"date-parts":[[2023,12,4]],"date-time":"2023-12-04T20:49:25Z","timestamp":1701722965000},"page":"171-183","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Acid\u2010suppressive drugs: A systematic review and network meta\u2010analysis of their nocturnal 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College Huazhong University of Science and Technology  Wuhan Hubei Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6226-8833","authenticated-orcid":false,"given":"Xuan","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1556-543X","authenticated-orcid":false,"given":"Minghui","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,12]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"294","article-title":"Adverse events of 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