{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:19:34Z","timestamp":1783487974086,"version":"3.55.0"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T00:00:00Z","timestamp":1705017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The introduction of the highly effective modulator therapy elexacaftor\u2010tezacaftor\u2010ivacaftor (ETI) has revolutionized the care of persons with cystic fibrosis (PwCF) with major improvements seen in lung function and body mass index. The effects of ETI therapy in real\u2010world cohorts on other parameters such as cholesterol levels are largely unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A single\u2010center, retrospective chart review study was conducted to assess the change in lipid panels before and after ETI initiation. The study investigated total cholesterol (TC), low\u2010density lipoprotein cholesterol (LDL\u2010C), high\u2010density lipoprotein cholesterol (HDL\u2010C), and triglyceride levels using both a univariate and multivariate mixed\u2010effects model to evaluate the change after initiation of ETI in a cohort of PwCF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 128 adult PwCF included in the analysis. Statistically significant changes were seen in both univariate and multivariate analyses for TC, LDL\u2010C, and HDL\u2010C. On multivariate analysis, TC increased by an average of 15.0\u2009mg\/dL after ETI initiation (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), LDL\u2010C increased by an average of 9.3\u2009mg\/dL (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and HDL\u2010C increased by an average of 3.8\u2009mg\/dL (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) after ETI initiation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this real\u2010world cohort of PwCF, cholesterol parameters increased after initiation with ETI therapy. Further consideration may need to be given for PwCF in regards to screening for cardiometabolic risk factors as PwCF age as well as the potential need for cholesterol\u2010lowering therapies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/phar.2903","type":"journal-article","created":{"date-parts":[[2023,12,24]],"date-time":"2023-12-24T22:53:11Z","timestamp":1703458391000},"page":"231-240","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Real world study on elexacaftor\u2010tezacaftor\u2010ivacaftor impact on cholesterol levels in adults with cystic fibrosis"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4285-1260","authenticated-orcid":false,"given":"Kevin","family":"Lonabaugh","sequence":"first","affiliation":[{"name":"University of Virginia Health  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galvin","family":"Li","sequence":"additional","affiliation":[{"name":"University of Virginia Health  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0385-7400","authenticated-orcid":false,"given":"Rhonda","family":"List","sequence":"additional","affiliation":[{"name":"University of Virginia Health  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5156-7694","authenticated-orcid":false,"given":"Reyna","family":"Huang","sequence":"additional","affiliation":[{"name":"University of Virginia Health  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3573-7486","authenticated-orcid":false,"given":"Amber","family":"James","sequence":"additional","affiliation":[{"name":"University of Virginia Health  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3523-0514","authenticated-orcid":false,"given":"Andrew","family":"Barros","sequence":"additional","affiliation":[{"name":"University of Virginia Health  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7052-0640","authenticated-orcid":false,"given":"Lindsay","family":"Somerville","sequence":"additional","affiliation":[{"name":"University of Virginia Health  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9055-3247","authenticated-orcid":false,"given":"Dana","family":"Albon","sequence":"additional","affiliation":[{"name":"University of Virginia Health  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2017.06.011"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.125.1_suppl.1S"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2016.03.004"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2009.09.002"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2021.05.002"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-022-01635-9"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2016.1182583"},{"key":"e_1_2_8_9_1","unstructured":"InformedHealth.org [Internet].Cologne Germany: Institute for Quality and Efficiency in health care (IQWiG); 2006. 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