{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T11:19:42Z","timestamp":1788779982650,"version":"build-2803163510"},"reference-count":1,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T00:00:00Z","timestamp":1717977600000},"content-version":"vor","delay-in-days":40,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Treatment options are currently limited for persons with HIV\u20101 (PWH) who are heavily treatment\u2010experienced and\/or have multidrug\u2010resistant HIV\u20101. Three agents have been approved by the U.S. Food and Drug Administration (FDA) since 2018, representing a significant advancement for this population: ibalizumab, fostemsavir, and lenacapavir. However, there is a paucity of recommendations endorsed by national and international guidelines describing the optimal use (e.g., selection and monitoring after initiation) of these novel antiretrovirals in this population. To address this gap, a modified Delphi technique was used to develop these consensus recommendations that establish a framework for initiating and managing ibalizumab, fostemsavir, or lenacapavir in PWH who are heavily treatment\u2010experienced and\/or have multidrug\u2010resistant HIV\u20101. In addition, future areas of research are also identified and discussed in the main document.<\/jats:p>","DOI":"10.1002\/phar.2913","type":"journal-article","created":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T03:34:45Z","timestamp":1717990485000},"page":"354-359","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Consensus recommendations for the use of novel antiretrovirals in persons with <scp>HIV<\/scp> who are heavily treatment\u2010experienced and\/or have multidrug\u2010resistant <scp>HIV<\/scp>\u20101: Endorsed by the American Academy of HIV Medicine, American College of Clinical Pharmacy: An executive summary"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3656-1144","authenticated-orcid":false,"given":"David B.","family":"Cluck","sequence":"first","affiliation":[{"name":"Department of Pharmacy Practice East Tennessee State University Bill Gatton College of Pharmacy  Johnson City Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4018-0195","authenticated-orcid":false,"given":"Daniel B.","family":"Chastain","sequence":"additional","affiliation":[{"name":"University of Georgia College of Pharmacy  Albany Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8748-185X","authenticated-orcid":false,"given":"Milena","family":"Murray","sequence":"additional","affiliation":[{"name":"Midwestern University College of Pharmacy  Downers Grove Illinois USA"},{"name":"Northwestern Medicine  Evanston Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6448-3879","authenticated-orcid":false,"given":"Spencer H.","family":"Durham","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice Auburn University Harrison College of Pharmacy  Auburn Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1775-9497","authenticated-orcid":false,"given":"Elias B.","family":"Chahine","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice Palm Beach Atlantic University Gregory School of Pharmacy  West Palm Beach Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4404-7965","authenticated-orcid":false,"given":"Caroline","family":"Derrick","sequence":"additional","affiliation":[{"name":"Prisma Health Midlands  Columbia South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3500-5819","authenticated-orcid":false,"given":"Julie B.","family":"Dumond","sequence":"additional","affiliation":[{"name":"Division of Pharmacotherapy and Experimental Therapeutics UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2985-4224","authenticated-orcid":false,"given":"E. 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Bartlett Specialty Practice  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7703-096X","authenticated-orcid":false,"given":"Wesley D.","family":"Kufel","sequence":"additional","affiliation":[{"name":"Binghamton University School of Pharmacy and Pharmaceutical Sciences  Binghamton New York USA"},{"name":"Division of Infectious Diseases State University of New York Upstate Medical University  Syracuse New York USA"},{"name":"State University of New York Upstate University Hospital  Syracuse New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Kwong","sequence":"additional","affiliation":[{"name":"Division of Advanced Practice, School of Nursing Rutgers, The State University of New Jersey  Newark New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber F.","family":"Ladak","sequence":"additional","affiliation":[{"name":"Ryan White Program, Division of Infectious Diseases Augusta University  Augusta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0921-549X","authenticated-orcid":false,"given":"Nimish","family":"Patel","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacy, Skaggs School of Pharmacy &amp; Pharmaceutical Sciences University of California, San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E.","family":"P\u00e9rez","sequence":"additional","affiliation":[{"name":"HIV and Primary Care Ruth M. Rothstein CORE Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonell B.","family":"Poe","sequence":"additional","affiliation":[{"name":"Ryan White Program, Division of Infectious Diseases Augusta University  Augusta Georgia USA"},{"name":"School of Allied Health Augusta University  Augusta Georgia USA"},{"name":"Department of Psychiatry, HIV\/LGBTQ Behavioral Track Augusta University  Augusta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9797-6557","authenticated-orcid":false,"given":"Charlotte","family":"Bolch","sequence":"additional","affiliation":[{"name":"Office of Research and Sponsored Programs Midwestern University  Glendale Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Thomas","sequence":"additional","affiliation":[{"name":"University of Georgia  Athens Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Asiago\u2010Reddy","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases State University of New York Upstate Medical University  Syracuse New York USA"},{"name":"Inclusive Health Services State University of New York Upstate Medical University  Syracuse New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William R.","family":"Short","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine Perelman School of Medicine at the University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,10]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/phar.2914"}],"container-title":["Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/phar.2913","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:56:59Z","timestamp":1761062219000},"score":1,"resource":{"primary":{"URL":"https:\/\/accpjournals.onlinelibrary.wiley.com\/doi\/10.1002\/phar.2913"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":1,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1002\/phar.2913"],"URL":"https:\/\/doi.org\/10.1002\/phar.2913","archive":["Portico"],"relation":{},"ISSN":["0277-0008","1875-9114"],"issn-type":[{"value":"0277-0008","type":"print"},{"value":"1875-9114","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"2023-10-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}