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In addition to their benefits in hyperglycemia, heart failure (HF), and kidney disease, their effects on obesity, metabolic dysfunction\u2010associated steatotic liver disease (MASLD, formerly named nonalcoholic fatty liver disease [NAFLD]), polycystic ovarian syndrome (PCOS), abnormal lipid metabolism, hyperuricemia, obstructive sleep apnea syndrome (OSAS), anemia, and syndrome of inappropriate antidiuresis (SIAD, formerly named syndrome of inappropriate antidiuretic hormone [SIADH]) have been explored. In this review, we searched the data of clinical randomized controlled trials (RCTs) and meta\u2010analyses of SGLTis in patients with diabetes from the PubMed library between January 1, 2020, and February 1, 2024. According to our review, certain SGLTis exhibit relatively superior clinical safety and effectiveness for treating the abovementioned diseases. Proper utilization of SGLTis in these patients can provide additional medication options for patients with different disease scenarios. However, studies of SGLTis in these diseases are relatively rare, with shortcomings such as small sample sizes and short intervention periods. Therefore, further large\u2010scale, long\u2010term, well\u2010designed studies are needed to clarify the findings.<\/jats:p>","DOI":"10.1002\/phar.2952","type":"journal-article","created":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T05:11:20Z","timestamp":1720415480000},"page":"642-657","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Update on the clinical applications of <scp>SGLTis<\/scp>: Insight to benefits beyond hypoglycemic and cardiorenal protection"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3403-7448","authenticated-orcid":false,"given":"Shibing","family":"Tao","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism West China Hospital of Sichuan University  Chengdu China"},{"name":"Research Centre for Diabetes and Metabolism West China Hospital of Sichuan University  Chengdu China"},{"name":"Department of Endocrinology and 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