{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:50:19Z","timestamp":1761094219234,"version":"build-2065373602"},"reference-count":43,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The objective of this scoping review was to answer the question, \u201cWhat has been published describing drug dosing in sustained low\u2010efficiency dialysis (SLED)?\u201d PubMed, Embase, and Scopus were searched on November 18, 2022. Methodology followed the Arksey and O'Malley framework for scoping reviews and Preferred Reporting Items for Systematic Reviews and Meta\u2010Analysis Extension for Scoping Reviews guidelines. Two investigators independently screened abstracts and full\u2010texts of citations identified related to drug dosing and SLED. Exclusion criteria included case reports, conference abstracts, pediatrics, treatment dialysis, and non\u2010human subjects. A standardized data extraction sheet was used to collate and summarize data. The quality of evidence was evaluated by two investigators using the Mixed Methods Appraisal Tool. A total of 230 citations were identified for screening. Of these, 29 studies met criteria for inclusion after full\u2010text review. Four drug groups including beta\u2010lactam antibiotics, non\u2010beta\u2010lactam antibiotics, antifungals, and levetiracetam were identified. Dialysate rates, dialysis durations, and medication doses used varied widely across studies. Outcomes and pharmacokinetic parameters that were assessed were also heterogenous. Drug dosing in SLED is challenging and there is minimal evidence available to guide appropriate dosing. Larger studies are needed to more accurately determine how to appropriately dose medications in SLED. Therapeutic drug monitoring should be used in all patients on SLED when available.<\/jats:p>","DOI":"10.1002\/phar.4628","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T00:07:16Z","timestamp":1734653236000},"page":"948-955","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Scoping review of drug dosing recommendations in sustained low\u2010efficiency dialysis"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5503-4043","authenticated-orcid":false,"given":"Nicholas R.","family":"Nelson","sequence":"first","affiliation":[{"name":"Department of Translational Science and Inpatient Practice Wingate University School of Pharmacy  Wingate North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9703-5845","authenticated-orcid":false,"given":"Nicholas J.","family":"Quinn","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Atrium Health Carolinas Medical Center  Charlotte North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8031-9860","authenticated-orcid":false,"given":"Stephanie","family":"Bills","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Atrium Health Carolinas Medical Center  Charlotte North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5733-6259","authenticated-orcid":false,"given":"Alexander","family":"Dellabella","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Atrium Health Carolinas Medical Center  Charlotte North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0971-1629","authenticated-orcid":false,"given":"Sarah E.","family":"Gregar","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Atrium Health Carolinas Medical Center  Charlotte North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5359-7853","authenticated-orcid":false,"given":"Alyssa","family":"Lear","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Atrium Health Union  Monroe North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4859-4272","authenticated-orcid":false,"given":"Legacy","family":"Marsolek","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Texas Health Harris Methodist Hospital  Fort Worth Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5428-3902","authenticated-orcid":false,"given":"Crystal","family":"Mounce","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Atrium Health Carolinas Medical Center  Charlotte North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6010-5301","authenticated-orcid":false,"given":"Morgan","family":"Tobin","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Atrium Health Carolinas Medical Center  Charlotte North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjaed\/mkw070"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000003701"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000002796"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0226325"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aes401"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00780207"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-015-0123-4"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/1364557032000119616"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.7326\/M18-0850"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.2307\/2529310"},{"key":"e_1_2_8_12_1","unstructured":"HongQ PluyeP F\u00e0breguesS et\u00a0al.Mixed Methods Appraisal Tool (MMAT) Version 2018. 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