{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T19:51:00Z","timestamp":1761162660127,"version":"build-2065373602"},"reference-count":51,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Laparoscopic cholecystectomy (LC) may cause significant pain, increasing morbidity. Granisetron, an antiemetic selective serotonin (5HT3)\u2010antagonist, demonstrates analgesic properties through sodium channel blockade. The current study aims to assess the efficacy of adjuvant intraperitoneal granisetron in post\u2010LC pain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Research Design and Methods<\/jats:title>\n                    <jats:p>In this prospective randomized controlled trial, 48 patients undergoing LC were randomized into placebo (intraperitoneal saline) and intervention (intraperitoneal granisetron) groups. Pain intensity was measured via visual analog scale (VAS) at 2\u2010, 4\u2010, 8\u2010, 12\u2010, and 24\u2010h post\u2010surgery, with comparative analysis of the area under the curve (AUC) of the 24\u2010h VAS scores. Additional outcomes included sedation levels, persistent pain incidence, quality of life improvement, postoperative nausea and vomiting (PONV), time to first rescue analgesic request, total analgesic consumption, and independent mobilization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The treatment group showed significantly lower VAS at 8, 12, and 24\u2009h (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.039, 0.004, 0.030) and lower VAS score AUC (542.7\u2009\u00b1\u2009260.5 vs. 767.1\u2009\u00b1\u2009317.8,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011) compared to controls, respectively. No significant differences were observed in (2\u20134\u2009h) pain scores, persistent pain incidence, quality of life, sedation levels, PONV, analgesic requirements, or mobilization time (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Granisetron could improve multimodal pain control after LC, offering better outcomes while maintaining its established safety profile.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>NCT06281418<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/phar.70046","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T09:55:38Z","timestamp":1753264538000},"page":"547-556","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intraperitoneal Granisetron for Post\u2010Laparoscopic Cholecystectomy Pain Management: A Double\u2010Blinded, Randomized Controlled Trial"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2435-982X","authenticated-orcid":false,"given":"Hoda Mohamed","family":"Bayoumi","sequence":"first","affiliation":[{"name":"Department of Pharmacy Practice and Clinical Pharmacy, Faculty of Pharmacy Future University in Egypt  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6088-7879","authenticated-orcid":false,"given":"Doaa Hamed","family":"Abdelaziz","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, Faculty of Pharmacy Al\u2010Baha University  Al\u2010Baha Saudi Arabia"},{"name":"Department of Clinical Pharmacy The National Hepatology and Tropical Medicine Research Institute  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sherif","family":"Boraii","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Pancreatic Surgery The National Hepatology and Tropical Medicine Research Institute  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1883-169X","authenticated-orcid":false,"given":"Ehab Rasmy","family":"Bendas","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Faculty of Pharmacy Cairo University  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5663-4924","authenticated-orcid":false,"given":"Nouran Omar","family":"El Said","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice and Clinical Pharmacy, Faculty of Pharmacy Future University in Egypt  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000035967"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.asjsur.2023.04.031"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2018.11.006"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17207571"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/jwas.jwas_57_23"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2015.04.083"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520510023675"},{"issue":"2","key":"e_1_2_10_9_1","first-page":"123","article-title":"Duloxetine, an Antidepressant With Analgesic Properties\u2014A Preliminary Analysis","volume":"22","author":"Onu\u0163u A. 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