{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T02:54:30Z","timestamp":1772765670586,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:00:00Z","timestamp":1762819200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Abrupt cessation of alcohol consumption after prolonged periods of use leaves patients at risk for experiencing withdrawal symptoms. Alcohol is a central nervous system depressant that increases the activity of the inhibitory neurotransmitter gamma\u2010aminobutyric acid (GABA) and suppresses the activity of the excitatory neurotransmitter glutamate. Stopping consumption of alcohol reduces this inhibitory response and leads to a net excitatory state and symptoms of withdrawal, including anxiety, tremors, and even seizures. Benzodiazepines have traditionally been the treatment of choice for patients with alcohol withdrawal. Gabapentin has recently been studied as an adjunctive agent for the treatment and prevention of alcohol withdrawal, given its structural similarity to GABA and lower risk for dependence compared with benzodiazepines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The primary objective of this study was to determine if a gabapentin\u2010based regimen is benzodiazepine\u2010sparing in patients experiencing alcohol withdrawal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a retrospective, single center, pre\u2010 and post\u2010implementation analysis of a gabapentin taper\u2010based alcohol withdrawal protocol in place of a traditional benzodiazepine\u2010based protocol used in patients admitted to a large, urban academic medical center in the Midwest for alcohol withdrawal between January 1, 2017, and January 1, 2023. The primary outcome was a comparison of cumulative benzodiazepine dose (in lorazepam equivalents) received throughout admission between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      This study included 200 patients with 100 patients in each of the pre\u2010 and post\u2010implementation groups. Baseline characteristics were similar between groups except for baseline serum alcohol level, which was higher in the pre\u2010implementation group. Patients in the post\u2010implementation group on average were exposed to 9.7\u2010mg lorazepam equivalents during admission compared with 22.8\u2010mg lorazepam equivalents in the pre\u2010implementation group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). Patients between groups had similar symptom progression as characterized by average daily alcohol withdrawal assessment scale (AWAS) scores and length of stay.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Utilization of a gabapentin taper resulted in significantly lower cumulative exposure to benzodiazepines and similar clinical outcomes in patients admitted for acute alcohol withdrawal.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/phar.70074","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T23:29:45Z","timestamp":1762903785000},"page":"746-753","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of Gabapentin as a Benzodiazepine\u2010Sparing Medication During Acute Alcohol Withdrawal"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2637-482X","authenticated-orcid":false,"given":"William G.","family":"Cordell","sequence":"first","affiliation":[{"name":"Department of Pharmacy The University of Kansas Health System Kansas City  Kansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7521-2153","authenticated-orcid":false,"given":"Leah A.","family":"Surbaugh","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice East Tennessee State University Bill Gatton College of Pharmacy  Johnson City Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4609-6100","authenticated-orcid":false,"given":"Kelsey","family":"Inman","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The University of Kansas Health System Kansas City  Kansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1490-0101","authenticated-orcid":false,"given":"Dennis","family":"Grauer","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice The University of Kansas School of Pharmacy  Kansas City Kansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8680-4860","authenticated-orcid":false,"given":"Megan","family":"Stewart","sequence":"additional","affiliation":[{"name":"The University of Missouri \u2013 Kansas City School of Pharmacy  Kansas City Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7113-730X","authenticated-orcid":false,"given":"Jace","family":"Knutson","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The University of Kansas Health System Kansas City  Kansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,11]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"National Survey on Drug Use and Health \u201cTable\u00a05.6A\u2014Alcohol Use Disorder in Past Year: Among People Aged 12 or Older; by Age Group and Demographic Characteristics Numbers in Thousands \u201dSAMHSA Center for Behavioral Health Statistics and Quality 2021 https:\/\/www.samhsa.gov\/data\/sites\/default\/files\/reports\/rpt39441\/NSDUHDetailedTabs2021\/NSDUHDetailedTabs2021\/NSDUHDetTabsSect5pe2021.htm#tab5.6a."},{"key":"e_1_2_9_3_1","unstructured":"A.Sharp \u201cAlcohol Withdrawal Symptoms Timeline Detox and Treatment \u201dAmerican Addiction Centers 2024 https:\/\/americanaddictioncenters.org\/withdrawal\u2010timelines\u2010treatments\/alcohol."},{"key":"e_1_2_9_4_1","volume-title":"StatPearls","author":"Newman R. 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