{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T06:21:55Z","timestamp":1791440515343,"version":"4.3.3"},"reference-count":67,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Peroxisome proliferator\u2010activated receptor \u03b1 (PPAR\u03b1) has been reported to exert protective roles in immune\u2010mediated intestinal diseases through inhibition of interleukin\u20106 (IL\u20106)\u2010induced signal transducer and activator of transcription factor 3 (STAT3) activation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To investigate the potential anti\u2010inflammatory effect of fenofibrate, as an add\u2010on therapy to mesalamine, on IL\u20106\/STAT3 and nitric oxide (NO) in patients with ulcerative colitis (UC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This pilot, double\u2010blind, randomized, controlled trial included 60 patients diagnosed with mild\u2010to\u2010moderate UC. Patients were randomly allocated into two groups. The placebo group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200930) received placebo plus mesalamine 1\u2009g three times daily, and the fenofibrate group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200930) received mesalamine 1\u2009g three times daily and fenofibrate 160\u2009mg once daily. The study duration was 6\u2009months. The severity of UC was evaluated using the Disease Activity Index (DAI), and quality of life (QoL) was assessed using the Short Form\u201036 questionnaire (SF\u201036). Serum levels of IL\u20106, NO, C\u2010reactive protein (CRP), and STAT3 were measured for all patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After treatment, both groups showed a significant reduction in DAI, IL\u20106, STAT3, NO, and CRP, along with an increase in SF\u201036 scores. Furthermore, the fenofibrate group demonstrated a significantly greater decrease in DAI (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0002), IL\u20106 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04), STAT3 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004), NO (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.013), and CRP (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.034), as well as a greater increase in SF\u201036 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04) compared with the placebo group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Fenofibrate may represent a promising add\u2010on therapy in patients with mild\u2010to\u2010moderate UC by modulating inflammation and improving QoL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>NCT05753267<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/phar.70088","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T03:56:11Z","timestamp":1764734171000},"page":"840-851","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Therapeutic Modulation of\n                    <scp>IL<\/scp>\n                    \u20106\/\n                    <scp>STAT<\/scp>\n                    \u20103 and Nitric Oxide by Fenofibrate in Patients With Ulcerative Colitis: A Randomized Controlled Pilot Study"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8649-3365","authenticated-orcid":false,"given":"Khlood Mohammad","family":"Aldossary","sequence":"first","affiliation":[{"name":"Department of Pharmacy Practice, College of Pharmacy Princess Nourah Bint Abdulrahman University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3237-1792","authenticated-orcid":false,"given":"Mahmoud S.","family":"Abdallah","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, Faculty of Pharmacy University of Sadat City (USC)  Sadat City Menoufia Egypt"},{"name":"Department of PharmD, Faculty of Pharmacy Jadara University  Irbid Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6737-9017","authenticated-orcid":false,"given":"Noha","family":"Kamal","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, Faculty of Pharmacy University of Sadat City (USC)  Sadat City Menoufia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7023-2454","authenticated-orcid":false,"given":"Mounir M.","family":"Bahgat","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Faculty of Medicine Mansoura University  Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Alrubia","sequence":"additional","affiliation":[{"name":"Pharmaceutical Chemistry Department, College of Pharmacy King Saud University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amsha S.","family":"Alsegiani","sequence":"additional","affiliation":[{"name":"Pharmaceutical Chemistry Department, College of Pharmacy King Saud University  Riyadh Saudi 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