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Clinical practice guidelines on post\u2010resuscitation cardiac arrest care from international medical organizations outline evidence\u2010based practices but sometimes lack pragmatic details needed by bedside clinicians to implement change. Lack of information has required providers to extrapolate from other patient populations with acute brain injuries or utilize lower quality data from patient registries or observational studies. We organized a group of content experts to address selected pharmacotherapeutic controversies encountered during temperature control after out\u2010of\u2010hospital cardiac arrest in adult patients. Data on pre\u2010hospital interventions, in\u2010hospital cardiac arrest, and most non\u2010pharmacologic treatments were excluded. A Delphi process was completed using three rounds of voting to reach consensus on pharmacotherapeutic controversies to review. The original list of 11 topics was narrowed iteratively and the final list included: (i) sedation and analgesia, (ii) seizures and myoclonus, (iii) shivering, and (iv) early\u2010onset pneumonia prevention. Writing groups conducted systematic literature searches of MEDLINE using PubMed focusing on contemporary publications in the past 30\u2009years when temperature control was considered standard care. Each section reviews the scope and management of the controversy and provides a conclusion with suggested future research directions. The information in this review is intended to support providers with the implementation of recommendations made in clinical practice guidelines on post\u2010resuscitation cardiac arrest care and should not necessarily supplant them.<\/jats:p>","DOI":"10.1002\/phar.70095","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T17:08:58Z","timestamp":1768583338000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pharmacotherapeutic Controversies During Temperature Control After Out\u2010of\u2010Hospital Cardiac Arrest: A Semi\u2010Structured Literature Review"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7523-0490","authenticated-orcid":false,"given":"Christy Cecil","family":"Forehand","sequence":"first","affiliation":[{"name":"Piedmont Augusta  Augusta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8811-2458","authenticated-orcid":false,"given":"Scott Thomas","family":"Benken","sequence":"additional","affiliation":[{"name":"University of Illinois Chicago College of Pharmacy  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1058-8181","authenticated-orcid":false,"given":"Melanie","family":"Madorsky","sequence":"additional","affiliation":[{"name":"Memorial Hermann Texas Medical Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3137-7049","authenticated-orcid":false,"given":"Adham","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Saint Luke's Hospital of Kansas City  Kansas City Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2990-6426","authenticated-orcid":false,"given":"Jerika V.","family":"Nguy\u1ec5n","sequence":"additional","affiliation":[{"name":"Trinity Health  Grand Rapids Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7960-0161","authenticated-orcid":false,"given":"Deepali","family":"Dixit","sequence":"additional","affiliation":[{"name":"Robert Wood Johnson University Hospital  New Brunswick New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolie","family":"Gallagher","sequence":"additional","affiliation":[{"name":"Emory University Hospital  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4083-7919","authenticated-orcid":false,"given":"William Anthony","family":"Hawkins","sequence":"additional","affiliation":[{"name":"Department of Clinical &amp; 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