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This resulted in a significant gap in knowledge regarding the safety and efficacy of medications for these populations. Maternal and Pediatric PRecision In Therapeutics Knowledge Portal (MPRINT\u2010KP) is designed to provide a comprehensive view of pharmacokinetic, pharmaco\u2010epidemiology, and clinical trial research evidence in maternal and pediatric patient populations. MPRINT\u2010KP Silver was generated upon BioBERT models, due to their supreme performance in classifying pharmacokinetic, pharmaco\u2010epidemiology, and clinical trial papers from PubMed, with an F1\u2010score &gt;\u20090.91. As of April 1, 2025, MPRINT\u2010KP Silver contains 758,560 clinical pharmacology research papers in maternal and pediatric populations. The landscape analysis revealed a large number of drugs with pharmacology knowledge gaps, which is calculated as the relative frequency of drugs with no or weak (i.e., less than five publications) evidence in each of pharmacokinetic, pharmaco\u2010epidemiology, or clinical trial study type. The highest pharmacotherapy knowledge gaps are in postpartum women, pregnant women, and pediatric patients between 0\u201312 and 12\u201318\u2009years of age (51.37%, 32.47%, 25.82%, 32.11%, respectively). Pharmacovigilance analyses were conducted on highly prescribed drugs with limited pharmacology evidence in pediatric patients 0\u20132\u2009year old and pregnant women using United States Food and Drug Administration Adverse Event Reporting System (FAERS) and MarketScan claims data. A number of new drug\u2010associated adverse drug events (ADEs) were discovered. In pediatric patients, there were crisaborole\u2010associated hemorrhage and moxifloxacin\u2010associated cardiac toxicities. In pregnant women, the analysis revealed terconazole\u2010associated abnormalities of heartbeat; benzonatate\u2010associated depressive and anxiety disorders; buspirone\u2010associated abnormalities of heartbeat; cyclobenzaprine\u2010associated tubulo\u2010interstitial nephritis; and pantoprazole\u2010associated hearing loss and voice and resonance disorders. For the first time, a large\u2010scale landscape analysis of pharmacotherapy knowledge gap in both maternal and pediatric patient populations was conducted and identified new drug associated ADE evidence using real world data.<\/jats:p>","DOI":"10.1002\/phar.70096","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T21:46:31Z","timestamp":1773006391000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Maternal and Pediatric Precision in Therapeutic Knowledge Portal (\n                    <scp>MPRINT<\/scp>\n                    \u2010\n                    <scp>KP<\/scp>\n                    ): Landscape Analysis of Pharmacology Research in Maternal and Pediatric Patient Populations"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5721-091X","authenticated-orcid":false,"given":"Xiaofu","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Biomedical Informatics, College of Medicine The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4123-7613","authenticated-orcid":false,"given":"Aditi","family":"Shendre","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics, College of Medicine The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1904-1737","authenticated-orcid":false,"given":"Lei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics, College of Medicine The Ohio State University  Columbus Ohio 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