{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T06:01:51Z","timestamp":1773036111511,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["accpjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacotherapy"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Linezolid is essential for drug\u2010resistant tuberculosis (DR\u2010TB) treatment but causes frequent hematological toxicity. We developed a time\u2010dependent nomogram to predict this risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A prospective cohort of 201 patients with DR\u2010TB receiving linezolid (600\u2009mg\/day) was enrolled. Blood trough concentration (C\n                      <jats:sub>min<\/jats:sub>\n                      ) and clinical variables were measured. Multivariable Cox regression identified predictors, with a nomogram constructed to estimate toxicity probability at 1, 3, and 6\u2009months. Model performance was assessed via calibration curves, C\u2010index, and time\u2010dependent area under the curve (AUC).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Ninety\u2010six patients (47.8%) developed hematological adverse events (anemia: 26.4%, leukopenia: 14.4%, thrombocytopenia: 7.0%). Five predictors were significant: C\n                      <jats:sub>min<\/jats:sub>\n                      \u2009&gt;\u20092.08\u2009mg\/L [Hazard Ratio (HR)\u2009=\u20092.87,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001]; lower baseline white blood cells (HR\u2009=\u20090.84,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003), hemoglobin (HR\u2009=\u20090.99,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.033), and creatinine clearance rate (HR\u2009=\u20090.99,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001); and initial treatment (HR\u2009=\u20090.56 vs. retreatment,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011). The nomogram showed good discrimination (C\u2010index\u2009=\u20090.73) and calibration. Time\u2010dependent AUCs were 0.74 (1\u2010month), 0.79 (3\u2010month), and 0.80 (6\u2010month). Internal validation via bootstrapping (1000\u00d7) confirmed robustness.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This nomogram, integrating C\n                      <jats:sub>min<\/jats:sub>\n                      with baseline clinical factors, enables early identification of patients with DR\u2010TB at high risk for hematotoxicity and could guide pre\u2010emptive interventions. However, external validation is required to confirm its generalizability before widespread clinical implementation.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/phar.70109","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T11:39:54Z","timestamp":1770637194000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Development and Validation of a Time\u2010Dependent Nomogram for Predicting Hematological Toxicity Risk During Linezolid Therapy in Drug\u2010Resistant Tuberculosis"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7375-7468","authenticated-orcid":false,"given":"Wenqiang","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Beijing Friendship Hospital, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Zhu","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Drug Resistance Tuberculosis Research, Beijing Tuberculosis and Thoracic Tumor Research Institute, and Beijing Chest Hospital, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongquan","family":"Liu","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Drug Resistance Tuberculosis Research, Beijing Tuberculosis and Thoracic Tumor Research Institute, and Beijing Chest Hospital, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjuan","family":"Nie","sequence":"additional","affiliation":[{"name":"Tuberculosis Department Beijing Chest Hospital, Capital Medical University  Beijing 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